Non-pulmonary lesions associated with a demonecrotic toxin-producing Pasteurella multocida D:3 infection in rabbits

Zamri Saad M., . and Al-Haddawi M. H., . and Mutalib A. R., . and Sheikh Omar A. R., . and Jasni S., . Non-pulmonary lesions associated with a demonecrotic toxin-producing Pasteurella multocida D:3 infection in rabbits. pp. 87-91. ISSN 9128-2506

Six New Zealand White rabbits inoculated intranasally with Pasteurella multocida D: 3 died acutely as early as day 3 post-infection and developed lesions in the liver kidney heart and brain apart from the nasal cavity trachea and lungs. Pasteurella multocida D: 3 was isolated from these organs. All affected organs were severely congested. There were diffused hepatocyte degeneration with cytoplasmic vacuolation particularly those around the portal triad and central veins. The hepatocyte enlargements resulted in narrowing of the sinusoids. Several Kupffer cells that lined the affected sinusoids appeared enlarged. The heart was haemorrhagic and the myocardial fibres were necrotic atrophied and separated by oedema. Heterophils and mononuclear cells infiltrated the myocardium. The pericardium was thickened with fibrin deposition and heterophil infiltration. Suppurative meningoencephalitis and axonal demyelination were observed in two rabbits that died at day 4 post-infection. Rabbits that survived until day 21 post-infection did not develop the non-pulmonary lesions and had no P. multocida in the non-pulmonary sites.

Full text available from: Official URL: https://www.mavma.org.my/1999-volume-11-issue-no-2...

Abstract

Six New Zealand White rabbits inoculated intranasally with Pasteurella multocida D: 3 died acutely as early as day 3 post-infection and developed lesions in the liver kidney heart and brain apart from the nasal cavity trachea and lungs. Pasteurella multocida D: 3 was isolated from these organs. All affected organs were severely congested. There were diffused hepatocyte degeneration with cytoplasmic vacuolation particularly those around the portal triad and central veins. The hepatocyte enlargements resulted in narrowing of the sinusoids. Several Kupffer cells that lined the affected sinusoids appeared enlarged. The heart was haemorrhagic and the myocardial fibres were necrotic atrophied and separated by oedema. Heterophils and mononuclear cells infiltrated the myocardium. The pericardium was thickened with fibrin deposition and heterophil infiltration. Suppurative meningoencephalitis and axonal demyelination were observed in two rabbits that died at day 4 post-infection. Rabbits that survived until day 21 post-infection did not develop the non-pulmonary lesions and had no P. multocida in the non-pulmonary sites.

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Item Type:	Article
AGROVOC Term:	Rabbits
AGROVOC Term:	Animal pathology
AGROVOC Term:	Inoculation
AGROVOC Term:	Pasteurella multocida
AGROVOC Term:	Lesions
AGROVOC Term:	Hepatocystis
AGROVOC Term:	Haemorrhage
AGROVOC Term:	Pneumonia
AGROVOC Term:	Heart
AGROVOC Term:	Pericardium
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8837

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