The immunomodulatory effects of Algammulin adjuvant on protection and antibody response to pseudorabies virus


Citation

Sheikh Omar A. R., . and Ali A. S., . and Bahaman A. R., . and Mohd Azmi M. L., . and Aini I., . The immunomodulatory effects of Algammulin adjuvant on protection and antibody response to pseudorabies virus. pp. 93-97. ISSN 9128-2506

Abstract

The potential of algammulin as adjuvant in the immune response to pseudorabies virus (PrV) was studied in mice. The antibody responses and protection against challenge were determined. A significant increase (p0.05) in the protection levels in mice immunised with at least 10 p. f.u. per mouse of algammulin-adjuvant PrV antigens were observed compared to those immunised with the PrV antigen without adjuvant. Total protection was obtained following immunisation of mice with 10� p.f.u. oer mouse. Following immunisation of mice antibody response was greater (p0.05) in mice immunised with the PrV antigen with adjuvant than in those immunised with the antigen alone. Booster dose using the algammulin-adjuvant PrV antigens slightly increased the antibody response. The antibody levels however were highly dose dependent.


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Abstract

The potential of algammulin as adjuvant in the immune response to pseudorabies virus (PrV) was studied in mice. The antibody responses and protection against challenge were determined. A significant increase (p0.05) in the protection levels in mice immunised with at least 10 p. f.u. per mouse of algammulin-adjuvant PrV antigens were observed compared to those immunised with the PrV antigen without adjuvant. Total protection was obtained following immunisation of mice with 10� p.f.u. oer mouse. Following immunisation of mice antibody response was greater (p0.05) in mice immunised with the PrV antigen with adjuvant than in those immunised with the antigen alone. Booster dose using the algammulin-adjuvant PrV antigens slightly increased the antibody response. The antibody levels however were highly dose dependent.

Additional Metadata

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Item Type: Article
AGROVOC Term: Adjuvants
AGROVOC Term: Vaccines
AGROVOC Term: Immune response
AGROVOC Term: Immunization
AGROVOC Term: Laboratory animals
AGROVOC Term: Pseudorabies virus
AGROVOC Term: Antigens
AGROVOC Term: Antibody formation
AGROVOC Term: Antibodies
AGROVOC Term: Dosage
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8838

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