The role of lipopolysaccharide of Pasteurella haemolytica in the development of experimental pasteurellosis in rabbits


Citation

Nor Izah A., . and M. Zamri Saad, . and Sheikh Omar A. R., . and Rasedee A., . and Heng H. G., . The role of lipopolysaccharide of Pasteurella haemolytica in the development of experimental pasteurellosis in rabbits. pp. 53-56. ISSN 9128-2506

Abstract

Twelve adult New Zealand white rabbits were divided into four groups before the first three groups were inoculated intravenously with 0.7 g/kg body weight 0.4 g/kg body weight and 0.2 g/kg body weight of lipopolysaccharide (LPS) isolated from Pasteurella haemolytica A2 respecticely. Rabbits in group 4 were the unexposed control. All rabbits were observed for signs of pasteurellosis while post mortem examinations were carried out on all dead rabbits. All rabbits in groups 1 2 and 3 were found dead within 24h post inoculation with lesions of peracute pasteurellosis which were mainly severe congestion of internal organs and haemorrhages in the tracheal mucosa and lungs. The control rabbits survived without any lesions. This report confirmed the ability of LPS isolated from P. haemolytica A2 to induce clinical signs and lesions similar to those of pasteurellosis in rabbits.


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Abstract

Twelve adult New Zealand white rabbits were divided into four groups before the first three groups were inoculated intravenously with 0.7 g/kg body weight 0.4 g/kg body weight and 0.2 g/kg body weight of lipopolysaccharide (LPS) isolated from Pasteurella haemolytica A2 respecticely. Rabbits in group 4 were the unexposed control. All rabbits were observed for signs of pasteurellosis while post mortem examinations were carried out on all dead rabbits. All rabbits in groups 1 2 and 3 were found dead within 24h post inoculation with lesions of peracute pasteurellosis which were mainly severe congestion of internal organs and haemorrhages in the tracheal mucosa and lungs. The control rabbits survived without any lesions. This report confirmed the ability of LPS isolated from P. haemolytica A2 to induce clinical signs and lesions similar to those of pasteurellosis in rabbits.

Additional Metadata

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Item Type: Article
AGROVOC Term: Pasteurellosis
AGROVOC Term: Pasteurella haemolytica
AGROVOC Term: Animal diseases
AGROVOC Term: Postmortem examination
AGROVOC Term: Rabbits
AGROVOC Term: Inoculation
AGROVOC Term: Lipopolysaccharides
AGROVOC Term: Disease occurrence
AGROVOC Term: Animal pathology
AGROVOC Term: Animal histology
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8864

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