Citation
Subhi A. B. N., . and M. Zamri Saad, . and M. S. Ismail, . and K. B. Khairul, . The effect of oxytetracycline on experimental Pasteurella multocida infection in rabbits. pp. 63-66. ISSN 9128-2506
Abstract
Thirty-six healthy New Zealand White rabbits were divided equally into four groups. Rabbits in group 1 were injected with a long acting oxytetracycline preparation at the rate of 20mg/kg two days prior to the intratracheal challenge with 10� colony forming unit (cfu)/mL of Pasteurella multocida type A. Rabbits in group 2 were challenged with P. multocida type A before the long acting oxytetracycline was injected two days later. Rabbits in group 3 were challenged with the same strain of P. multocida but were not treated with the antibiotic while rabbits in group 4 were injected with the antibiotic without challenge with P. multocida type A. Three rabbits in group 2 and 8 rabbits in group 3 died within 5 days post challenge. The extent of lung lesions in rabbits in group 2 that survived decreased while the only rabbit that survived in group 3 showed severe and extensive lung lesions on post mortem. None of the rabbits in groups 1 and 4 died and on post mortem no lesions on the lung were seen. The serum level of oxytetracycline was highest at 6h post-injection before the level gradually reduced to a low level as early as 48 h. Rabbits that survived were killed at days 3 7 11 and 14 post antibiotic treatment.
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Abstract
Thirty-six healthy New Zealand White rabbits were divided equally into four groups. Rabbits in group 1 were injected with a long acting oxytetracycline preparation at the rate of 20mg/kg two days prior to the intratracheal challenge with 10� colony forming unit (cfu)/mL of Pasteurella multocida type A. Rabbits in group 2 were challenged with P. multocida type A before the long acting oxytetracycline was injected two days later. Rabbits in group 3 were challenged with the same strain of P. multocida but were not treated with the antibiotic while rabbits in group 4 were injected with the antibiotic without challenge with P. multocida type A. Three rabbits in group 2 and 8 rabbits in group 3 died within 5 days post challenge. The extent of lung lesions in rabbits in group 2 that survived decreased while the only rabbit that survived in group 3 showed severe and extensive lung lesions on post mortem. None of the rabbits in groups 1 and 4 died and on post mortem no lesions on the lung were seen. The serum level of oxytetracycline was highest at 6h post-injection before the level gradually reduced to a low level as early as 48 h. Rabbits that survived were killed at days 3 7 11 and 14 post antibiotic treatment.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Pasteurellosis |
| AGROVOC Term: | Pasteurella multocida |
| AGROVOC Term: | Animal diseases |
| AGROVOC Term: | Bacterial diseases |
| AGROVOC Term: | Disease occurrence |
| AGROVOC Term: | Rabbits |
| AGROVOC Term: | Oxytetracycline |
| AGROVOC Term: | Antibiotics |
| AGROVOC Term: | Postmortem examination |
| AGROVOC Term: | Infection |
| Depositing User: | Mr. AFANDI ABDUL MALEK |
| Last Modified: | 24 Apr 2025 00:54 |
| URI: | http://webagris.upm.edu.my/id/eprint/8866 |
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