Immunology of ovine gastrointestinal nematodoses


Citation

Israf D. A., . Immunology of ovine gastrointestinal nematodoses. pp. 39-46. ISSN 9128-2506

Abstract

The immune response to ovine gastrointestinal nematode infections is reviewed. The response is discussed according to the major cells/molecules involved although one must bear in mind the interrelationship of these complex units. The antibody response involves elevation of systemic and local IgG and local IgA concentrations with increased numbers of antibody-secreting cells in the vicinity of the parasitized tissue. T cells play a crucial role in the immune response and recent findings suggest that the CD4� T cell subset may play an important role in developing immunity. The inflammatory response involves a local mastocytosis and local and systemic eosinophilia and these cells are believed to produce mediators which lead to the various effects of developing immunity upon the parasites. The role of mucus in trapping and providing a medium for delivery of antibodies and mediators to the parasite is discussed.


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Abstract

The immune response to ovine gastrointestinal nematode infections is reviewed. The response is discussed according to the major cells/molecules involved although one must bear in mind the interrelationship of these complex units. The antibody response involves elevation of systemic and local IgG and local IgA concentrations with increased numbers of antibody-secreting cells in the vicinity of the parasitized tissue. T cells play a crucial role in the immune response and recent findings suggest that the CD4� T cell subset may play an important role in developing immunity. The inflammatory response involves a local mastocytosis and local and systemic eosinophilia and these cells are believed to produce mediators which lead to the various effects of developing immunity upon the parasites. The role of mucus in trapping and providing a medium for delivery of antibodies and mediators to the parasite is discussed.

Additional Metadata

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Item Type: Article
AGROVOC Term: Nematodes
AGROVOC Term: Parasitic diseases
AGROVOC Term: Gastrointestinal diseases
AGROVOC Term: Animal husbandry
AGROVOC Term: Sheep
AGROVOC Term: Immunology
AGROVOC Term: Antibodies
AGROVOC Term: Immunoglobulins
AGROVOC Term: Antibody formation
AGROVOC Term: Inflammation
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:54
URI: http://webagris.upm.edu.my/id/eprint/8877

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