Physicochemical characterization of quercetin-loaded liposomes prepared by sonication for functional food application

Nur Amalina Ramli, . and Nora’aini Ali, . and Sofiah Hamzah, . Physicochemical characterization of quercetin-loaded liposomes prepared by sonication for functional food application. pp. 15-27. ISSN 2672-7226

This research was intended to synthesize liposome as a nanocarrier to encapsulate quercetin which is prone to degradation and susceptible to low bioavailability upon oral administration. The liposomes were synthesized by thin-film hydration method and followed by probe sonication for downsizing. Soy phosphatidylcholine (SPC) and cholesterol (CHOL) were employed as the composition of the phospholipid bilayer. Results indicated a dependence of sonication amplitude and time in the formation of free liposomes (FL). The average size of quercetin-loaded liposomes (QL) prepared was 346.4 nm with a narrow polydispersity index (0.22) and a high magnitude of zeta potential (-49.6 mV). These characterizations depict that a homogenous nanovesicle suspension with high stability was successfully synthesized. Quercetin was incorporated into the liposomes with a high encapsulation efficiency of 90.7 and loading capacity of 9.3. This viable nanocarrier perhaps will provide ingenious protection for a wider spectrum of active agents in food and biopharmaceutical products.

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Abstract

This research was intended to synthesize liposome as a nanocarrier to encapsulate quercetin which is prone to degradation and susceptible to low bioavailability upon oral administration. The liposomes were synthesized by thin-film hydration method and followed by probe sonication for downsizing. Soy phosphatidylcholine (SPC) and cholesterol (CHOL) were employed as the composition of the phospholipid bilayer. Results indicated a dependence of sonication amplitude and time in the formation of free liposomes (FL). The average size of quercetin-loaded liposomes (QL) prepared was 346.4 nm with a narrow polydispersity index (0.22) and a high magnitude of zeta potential (-49.6 mV). These characterizations depict that a homogenous nanovesicle suspension with high stability was successfully synthesized. Quercetin was incorporated into the liposomes with a high encapsulation efficiency of 90.7 and loading capacity of 9.3. This viable nanocarrier perhaps will provide ingenious protection for a wider spectrum of active agents in food and biopharmaceutical products.

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Item Type:	Article
AGROVOC Term:	Fabaceae
AGROVOC Term:	Soy beans
AGROVOC Term:	Quercetin
AGROVOC Term:	Functional foods
AGROVOC Term:	Bioavailability
AGROVOC Term:	Encapsulation
AGROVOC Term:	Phosphatidylcholines
AGROVOC Term:	Phospholipids
AGROVOC Term:	Chloroform
AGROVOC Term:	Methanol
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/9222

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