Pattern of histopathological alterations in N-methyl-N-Nitrosourea (MNU) induced breast cancer in female Sprague Dawley (SD) rats treated with crude honey

Nur Asyilla Che Jalil, . and Ahamed Sarfarz, . and Wan Faiziah Wan Abdul Rahman, . and Banik Urmila, . and Latt Swe Swe, . and Nor Hayati Othman, . Pattern of histopathological alterations in N-methyl-N-Nitrosourea (MNU) induced breast cancer in female Sprague Dawley (SD) rats treated with crude honey. pp. 1549-1558. ISSN 2231-8526

Natural products are becoming primary investigative molecules creating hope for finding new powerful classes of anticancer agents for breast cancer. One of the most remarkable of these is honey. To explore the mechanism of action of any anticancer agent the initial step is to analyse its effect in the histopathological tissue section. This study was designed to describe the histopathology of N-methylN-nitrosourea (MNU) induced breast cancer in Sprague Dawley rat (SD rats) treated with crude honey. Female rats were distributed into 4 groups: Group0 (normal) Group1 (MNU control) Group2 and 3: Tualang and Manuka honey-treated respectively. Rats were sacrificed and histopathology of both non-treated and treated tumours was done. Lower histological grade infrequent combination histologic pattern (p0.001) prominent cytoplasmic vacuolization (p0.001) aggregates of atypical macrophages (p 0.001) and lesser necrosis (p 0.005) were major outcomes in treated cancers. This data will aid in the histopathological interpretation of honey-treated breast cancer model and future anticancer study of honey.

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Abstract

Natural products are becoming primary investigative molecules creating hope for finding new powerful classes of anticancer agents for breast cancer. One of the most remarkable of these is honey. To explore the mechanism of action of any anticancer agent the initial step is to analyse its effect in the histopathological tissue section. This study was designed to describe the histopathology of N-methylN-nitrosourea (MNU) induced breast cancer in Sprague Dawley rat (SD rats) treated with crude honey. Female rats were distributed into 4 groups: Group0 (normal) Group1 (MNU control) Group2 and 3: Tualang and Manuka honey-treated respectively. Rats were sacrificed and histopathology of both non-treated and treated tumours was done. Lower histological grade infrequent combination histologic pattern (p0.001) prominent cytoplasmic vacuolization (p0.001) aggregates of atypical macrophages (p 0.001) and lesser necrosis (p 0.005) were major outcomes in treated cancers. This data will aid in the histopathological interpretation of honey-treated breast cancer model and future anticancer study of honey.

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Item Type:	Article
AGROVOC Term:	Honey
AGROVOC Term:	Disease treatment
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Laboratory experimentation
AGROVOC Term:	Laboratory animals
AGROVOC Term:	Histopathology
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/9360

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