Exploring potential neuroprotective properties of aqueous Centella asiatica extract in chronic stress-induced rats


Citation

Fatin Nadzirah Zakaria, . and Muhammad Zaim Zainal Abidin, . and Zulkhairi Amom, . and Nina Keterina Hashim, . and Muhamad Zulhusni Abdul Wahab, . and Razif Dasiman, . and Mohamad Aris Mohd Moklas, . Exploring potential neuroprotective properties of aqueous Centella asiatica extract in chronic stress-induced rats. pp. 1561-1574. ISSN 2231-8526

Abstract

Centella asiatica is one of the traditional herbs consumed by many communities due to its wide range of applications such as treating Parkinsonism promoting memory enhancement and preventing oxidative stress. This study was conducted to investigate the neuroprotective potential of aqueous C. asiatica extract (CAE) against neurodegeneration induced by chronic stress. Administration of CAE at three different dosages (200 mg/kg/day 400 mg/ kg/day and 800 mg/kg/day) was conducted for a period of 21 days along with exposure to chronic stress using restrainer and forced swimming regimes. The administration of CAE significantly improved the thickness of dentate gyrus and reduced the amount of neuronal cell death at dentate gyrus and CA3 (p0.05). Additionally administration of CAE significantly alleviated the expression c-fos protein (p0.05). Thus this study highlighted the neuroprotective effect of CAE against neurodegeneration from chronic stress exposure.


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Abstract

Centella asiatica is one of the traditional herbs consumed by many communities due to its wide range of applications such as treating Parkinsonism promoting memory enhancement and preventing oxidative stress. This study was conducted to investigate the neuroprotective potential of aqueous C. asiatica extract (CAE) against neurodegeneration induced by chronic stress. Administration of CAE at three different dosages (200 mg/kg/day 400 mg/ kg/day and 800 mg/kg/day) was conducted for a period of 21 days along with exposure to chronic stress using restrainer and forced swimming regimes. The administration of CAE significantly improved the thickness of dentate gyrus and reduced the amount of neuronal cell death at dentate gyrus and CA3 (p0.05). Additionally administration of CAE significantly alleviated the expression c-fos protein (p0.05). Thus this study highlighted the neuroprotective effect of CAE against neurodegeneration from chronic stress exposure.

Additional Metadata

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Item Type: Article
AGROVOC Term: Rats
AGROVOC Term: Herbs (herbaceous plants)
AGROVOC Term: Stress
AGROVOC Term: Hippocampus (genus)
AGROVOC Term: Extraction
AGROVOC Term: Experiments
AGROVOC Term: Sampling
AGROVOC Term: Experimental design
AGROVOC Term: Statistical analysis
AGROVOC Term: Analysis of variance
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:55
URI: http://webagris.upm.edu.my/id/eprint/9386

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