Effects of sugarcane vinegar supplementation on oxidative stress and weight reduction in hyperlipidaemic mice

Zheng F. J., . and Chen G. L., . and Lin B., . and Khoo H. E., . and Li Z. C., . and Fang X. C., . and Sun J., . Effects of sugarcane vinegar supplementation on oxidative stress and weight reduction in hyperlipidaemic mice. pp. 1121-1131. ISSN 2231-7546

The present work aimed to evaluate the efficacy of sugarcane vinegar supplementation in hyperlipidaemic mice. The mice were divided into six experimental groups: negative control positive control (hyperlipidaemic) lovastatin low-dose medium-dose and high-dose supplementation groups that received sugarcane vinegar via force-feeding. Body and organ weights of the mice were measured at the end of the study and the collected blood was subjected to analysis of plasma lipid profile plasma antioxidant enzymes and other biochemical parameters for protection against oxidative stress. The results revealed that sugarcane vinegar supplementation significantly reduced body weight and improved plasma lipid profile of the mice. Although mice from the high-dose group showed a significant reduction in plasma triglyceride and plasma low-density lipoprotein-cholesterol no changes in plasma total cholesterol and plasma high-density lipoprotein-cholesterol were observed. Supplementation of sugarcane vinegar in hyperlipidaemic mice neither reduced plasma glucose levels inhibited plasma -amylase activity nor increased plasma lipase levels when compared with non-supplemented hyperlipidaemic mice. Oxidative stress was slightly improved in mice in response to supplementation with sugarcane vinegar where all supplemented mice exhibited a significantly lower plasma malondialdehyde level and the mice from the high-dose group exhibited a significantly higher plasma superoxide dismutase level when compared with the hyperlipidaemic group. As sugarcane vinegar reduced oxidative stress in mice especially in mice supplemented with a high dosage of the vinegar sugarcane vinegar could be a functional food with great potential for use in health-promoting beverages.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/27%20(06)%202020/DONE%2...

Abstract

The present work aimed to evaluate the efficacy of sugarcane vinegar supplementation in hyperlipidaemic mice. The mice were divided into six experimental groups: negative control positive control (hyperlipidaemic) lovastatin low-dose medium-dose and high-dose supplementation groups that received sugarcane vinegar via force-feeding. Body and organ weights of the mice were measured at the end of the study and the collected blood was subjected to analysis of plasma lipid profile plasma antioxidant enzymes and other biochemical parameters for protection against oxidative stress. The results revealed that sugarcane vinegar supplementation significantly reduced body weight and improved plasma lipid profile of the mice. Although mice from the high-dose group showed a significant reduction in plasma triglyceride and plasma low-density lipoprotein-cholesterol no changes in plasma total cholesterol and plasma high-density lipoprotein-cholesterol were observed. Supplementation of sugarcane vinegar in hyperlipidaemic mice neither reduced plasma glucose levels inhibited plasma -amylase activity nor increased plasma lipase levels when compared with non-supplemented hyperlipidaemic mice. Oxidative stress was slightly improved in mice in response to supplementation with sugarcane vinegar where all supplemented mice exhibited a significantly lower plasma malondialdehyde level and the mice from the high-dose group exhibited a significantly higher plasma superoxide dismutase level when compared with the hyperlipidaemic group. As sugarcane vinegar reduced oxidative stress in mice especially in mice supplemented with a high dosage of the vinegar sugarcane vinegar could be a functional food with great potential for use in health-promoting beverages.

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Item Type:	Article
AGROVOC Term:	Sugarcane
AGROVOC Term:	Vinegar
AGROVOC Term:	Food supplementation
AGROVOC Term:	Laboratory experimentation
AGROVOC Term:	Hyperlipidaemia
AGROVOC Term:	Experimental animals
AGROVOC Term:	Phenolic compounds
AGROVOC Term:	Antioxidants
AGROVOC Term:	Oxidative stress
AGROVOC Term:	Weight reduction
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/9454

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