Adiponectin anthropometric measurements and insulin resistance in adolescence with obesity

Meta Herdiana Hanindita, . and Rendi Aji Prihaningtyas, . and Roedi Irawan, . and IDG Ugrasena, . and Nur Aisiyah Widjaja, . and Retno Handajani, . Adiponectin anthropometric measurements and insulin resistance in adolescence with obesity. pp. 165-172. ISSN 1394–035X

Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin resistance increases the risk of metabolic syndrome which then increases the risk of premature death. Studies about anthropometric measurements and adiponectin levels as early markers of insulin resistance in obese adolescents are still limited. Methods: A cross-sectional study was performed on 59 obese adolescents aged 13“16 years. Obesity was established on the basis of the Centers for Disease Control and Prevention (CDC) curve (2000). Insulin and blood glucose level measurements were carried out using an enzymatic kit. Adiponectin levels were assayed using enzyme-linked immunosorbent assay (ELISA). The relationships between variables were evaluated by correlation analysis using SPSS. Results: Statistical tests showed a positive correlation between waist circumference (r0.421; p0.001) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r0.396; p0.002). Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) had a weak positive correlation with insulin (r0.343; p0.008 and r0.311; p0.017) and HOMA-IR (r0.306; p0.018). There was a weak negative correlation between adiponectin and insulin in obese adolescents (r-0.278; p0.033). Conclusion: Anthropometric measurements (waist circumference WHR and WHtR) and adiponectin can be used for early detection of insulin resistance and hyperinsulinemia in obese adolescents.

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Abstract

Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin resistance increases the risk of metabolic syndrome which then increases the risk of premature death. Studies about anthropometric measurements and adiponectin levels as early markers of insulin resistance in obese adolescents are still limited. Methods: A cross-sectional study was performed on 59 obese adolescents aged 13“16 years. Obesity was established on the basis of the Centers for Disease Control and Prevention (CDC) curve (2000). Insulin and blood glucose level measurements were carried out using an enzymatic kit. Adiponectin levels were assayed using enzyme-linked immunosorbent assay (ELISA). The relationships between variables were evaluated by correlation analysis using SPSS. Results: Statistical tests showed a positive correlation between waist circumference (r0.421; p0.001) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r0.396; p0.002). Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) had a weak positive correlation with insulin (r0.343; p0.008 and r0.311; p0.017) and HOMA-IR (r0.306; p0.018). There was a weak negative correlation between adiponectin and insulin in obese adolescents (r-0.278; p0.033). Conclusion: Anthropometric measurements (waist circumference WHR and WHtR) and adiponectin can be used for early detection of insulin resistance and hyperinsulinemia in obese adolescents.

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Item Type:	Article
AGROVOC Term:	Adolescents (people)
AGROVOC Term:	Obesity
AGROVOC Term:	Biochemistry
AGROVOC Term:	Anthropometry
AGROVOC Term:	Insulin
AGROVOC Term:	Blood glucose
AGROVOC Term:	Metabolic disorders
AGROVOC Term:	Body weight
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/9749

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