Fish oil capsule supplementation in children with obesity reduced c-reactive protein and improved blood pressure

Sidiartha I Gusti Lanang, . and Vedaswari Putu Diah, . and Suryawan I Wayan Bikin, . Fish oil capsule supplementation in children with obesity reduced c-reactive protein and improved blood pressure. pp. 453-460. ISSN 1394–035X

Introduction: Excessive accumulation of body fat in obesity increases morbidities such as hypertension and cardiovascular diseases. This study investigated the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the level of high-sensitivity C-reactive protein (hs-CRP) and blood pressure in children with obesity. Methods: Fifty obese children aged 6-10 years were randomly assigned to the supplementation group (n25) who received EPA and DHA supplementation or to the placebo group (n25) for eight weeks. The trial was done in a single centre in Denpasar Bali Indonesia. Randomisation and allocation to the trial group were done by a computer system. The primary analysis was comparing the blood pressure and hs-CRP level between groups. Analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) tests were done to compare the differences between groups with a p-value 0.05 considered as significant. Results: A total of 44 children completed the study 24 (54.5) were males and 20 (45.5) were females. Initially the systolic/diastolic blood pressure and hs-CRP level in the supplementation and placebo groups were 109.5/72.7 mmHg and 3.5 mg/L 107.9/68.4 mmHg and 2.8 mg/L respectively. At the end they were 106.3/67.7 mmHg and 1.7 mg/L and 108.1/71.8 mmHg and 2.8 mg/L respectively. Systolic- diastolic blood pressure and hs-CRP level were decreased by -2.6 mmHg (95 CI: -6.9 to 1.6; p0.220) -7.5 mmHg (95 CI: -12.4 to -2.6; p0.004) and -1.15 mg/L (95 CI: -2.1 to -0.2; p0.022) respectively. Conclusion: EPA and DHA supplementation in obese children showed significant decrease in diastolic blood pressure and hs-CRP level.

Full text available from: Official URL: https://nutriweb.org.my/mjn/publication/26-3/Vol%2...

Abstract

Introduction: Excessive accumulation of body fat in obesity increases morbidities such as hypertension and cardiovascular diseases. This study investigated the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on the level of high-sensitivity C-reactive protein (hs-CRP) and blood pressure in children with obesity. Methods: Fifty obese children aged 6-10 years were randomly assigned to the supplementation group (n25) who received EPA and DHA supplementation or to the placebo group (n25) for eight weeks. The trial was done in a single centre in Denpasar Bali Indonesia. Randomisation and allocation to the trial group were done by a computer system. The primary analysis was comparing the blood pressure and hs-CRP level between groups. Analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) tests were done to compare the differences between groups with a p-value 0.05 considered as significant. Results: A total of 44 children completed the study 24 (54.5) were males and 20 (45.5) were females. Initially the systolic/diastolic blood pressure and hs-CRP level in the supplementation and placebo groups were 109.5/72.7 mmHg and 3.5 mg/L 107.9/68.4 mmHg and 2.8 mg/L respectively. At the end they were 106.3/67.7 mmHg and 1.7 mg/L and 108.1/71.8 mmHg and 2.8 mg/L respectively. Systolic- diastolic blood pressure and hs-CRP level were decreased by -2.6 mmHg (95 CI: -6.9 to 1.6; p0.220) -7.5 mmHg (95 CI: -12.4 to -2.6; p0.004) and -1.15 mg/L (95 CI: -2.1 to -0.2; p0.022) respectively. Conclusion: EPA and DHA supplementation in obese children showed significant decrease in diastolic blood pressure and hs-CRP level.

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Item Type:	Article
AGROVOC Term:	Children
AGROVOC Term:	Obesity
AGROVOC Term:	Clinical trials
AGROVOC Term:	Fish oils
AGROVOC Term:	Docosahexaenoic acid
AGROVOC Term:	Eicosapentaenoic acid
AGROVOC Term:	Cytokines
AGROVOC Term:	Blood pressure
AGROVOC Term:	Inflammation
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/9781

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