Response of Channa striatus extract against MIA induced osteoarthritis in the rat


Citation

F. J. Al-Saffar, . and S. Ganabadi, . and S. Fakurazi, . and H. Yaakub, . (2009) Response of Channa striatus extract against MIA induced osteoarthritis in the rat. [Proceedings Paper]

Abstract

The objective of his study was to evaluate chondroprotective effect of oral administration of Channa striatus common name Haruan extract against monosodium iodoacetate MIA induced stifle osteoarthritis OA in the rat. Forty adult male Sprague Dawley rats were divided into four groups n 10 each group. Rats in the first and second groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the third group were treated with Celebrex and served as positive control where as the fourth group was treated with normal saline and served as a negative control. Prior to treatment all animals were injected with MIA intra-articularly in their right knee joints to induce OA Evaluation of OA changes in the knees was assessed with the aid of both radiography and histopathology score. Gross and microscopic results revealed curative effects of the extract on the OA joints.


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Abstract

The objective of his study was to evaluate chondroprotective effect of oral administration of Channa striatus common name Haruan extract against monosodium iodoacetate MIA induced stifle osteoarthritis OA in the rat. Forty adult male Sprague Dawley rats were divided into four groups n 10 each group. Rats in the first and second groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the third group were treated with Celebrex and served as positive control where as the fourth group was treated with normal saline and served as a negative control. Prior to treatment all animals were injected with MIA intra-articularly in their right knee joints to induce OA Evaluation of OA changes in the knees was assessed with the aid of both radiography and histopathology score. Gross and microscopic results revealed curative effects of the extract on the OA joints.

Additional Metadata

[error in script]
Item Type: Proceedings Paper
Additional Information: 2 tables
AGROVOC Term: Osteoarthritis
AGROVOC Term: Cartilage
AGROVOC Term: Channa striatus
AGROVOC Term: Rats
AGROVOC Term: Oral administration
Geographical Term: MALAYSIA
Depositing User: Ms. Norfaezah Khomsan
Last Modified: 24 Apr 2025 05:27
URI: http://webagris.upm.edu.my/id/eprint/15790

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