Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells

Ng Kay Lee, . and Ammu Kutty Radhakrishnan, . and Kanga Rani Selvaduray, . Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells. pp. 251-261. ISSN 1511-2780

Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells

Full text available from: Official URL: http://jopr.mpob.gov.my/apoptosis-gene-network-reg...

Abstract

Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells

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Item Type:	Article
AGROVOC Term:	Apoptosis
AGROVOC Term:	Programmed cell death
AGROVOC Term:	Cell death
AGROVOC Term:	Leukaemia
AGROVOC Term:	Human diseases
AGROVOC Term:	Cell culture
AGROVOC Term:	Centrifugation
AGROVOC Term:	Extraction
AGROVOC Term:	In vitro
AGROVOC Term:	Ribonucleic acid
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:28
URI:	http://webagris.upm.edu.my/id/eprint/24158

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