Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells


Citation

Ng Kay Lee, . and Ammu Kutty Radhakrishnan, . and Kanga Rani Selvaduray, . Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells. pp. 251-261. ISSN 1511-2780

Abstract

Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells


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Abstract

Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells

Additional Metadata

[error in script]
Item Type: Article
AGROVOC Term: Apoptosis
AGROVOC Term: Programmed cell death
AGROVOC Term: Cell death
AGROVOC Term: Leukaemia
AGROVOC Term: Human diseases
AGROVOC Term: Cell culture
AGROVOC Term: Centrifugation
AGROVOC Term: Extraction
AGROVOC Term: In vitro
AGROVOC Term: Ribonucleic acid
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:28
URI: http://webagris.upm.edu.my/id/eprint/24158

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