Citation
Ng Kay Lee, . and Ammu Kutty Radhakrishnan, . and Kanga Rani Selvaduray, . Apoptosis gene network regulated by delta-tocotrienol in K562 chronic myeloid leukaemia cells. pp. 251-261. ISSN 1511-2780
Abstract
Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells
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Abstract
Palm oil is rich in various health-beneficial phytonutrients. The vitamin E and the carotenoids make up a large portion of these phytonutrients. The tocotrienols are a relatively newer class of vitamin E isoforms that are actively being researched for its various health promoting properties. In this study the anti-cancer properties of the delta-tocotrienol (´-T3) isoform were investigated on a leukemic cell line. A preliminary cytotoxicity assay was carried out to identify ´-T3s potency in inducing cell death. Following this a real time-based gene array experiment was carried out to distinguish the apoptosis genes regulated by ´-T3 in the K562 leukemic cell line. Results show that treatment with ´-T3 significant regulated the expression of several genes that promote apoptosis such as TP53 TP73 HRK MCL1 CASP7 CASP8 DAPK1 PYCARD FASLG and TNFRSF9. These findings suggest that palm ´-T3 can exert anti-cancer activities in chronic myeloid leukemic cells
Additional Metadata
Item Type: | Article |
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AGROVOC Term: | Apoptosis |
AGROVOC Term: | Programmed cell death |
AGROVOC Term: | Cell death |
AGROVOC Term: | Leukaemia |
AGROVOC Term: | Human diseases |
AGROVOC Term: | Cell culture |
AGROVOC Term: | Centrifugation |
AGROVOC Term: | Extraction |
AGROVOC Term: | In vitro |
AGROVOC Term: | Ribonucleic acid |
Depositing User: | Ms. Suzila Mohamad Kasim |
Last Modified: | 24 Apr 2025 06:28 |
URI: | http://webagris.upm.edu.my/id/eprint/24158 |
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