Comparison of anthropometric profile bone-related parameters biochemical parameters functional capacity and vitamin D status “ a study on postmenopausal Malaysian women

Nurdiana Z. Abidin, . and Soma R. Mitra, . Comparison of anthropometric profile bone-related parameters biochemical parameters functional capacity and vitamin D status “ a study on postmenopausal Malaysian women. pp. 233-246. ISSN 1394–035X

Introduction: The optimal level of total 25(OH)D in Malaysian postmenopausal women that is necessary to ameliorate the combined effects of decreased bone mineral and muscle mass and increase in adiposity as seen in osteosarcopenic obesity is unknown. Given that these are common pathologies existing in bone muscle and excess fat-related disorders this study investigated the association between body composition functional capacity and total 25(OH)D levels. Methods: This was a cross-sectional study involving 117 postmenopausal Malaysian women aged 50-88 years. Total 25(OH)D was analysed by chemiluminescent microparticle immunoassay CMIA on Siemens platforms. Bone mineral was measured by broadband ultrasound attenuation. Functional performance was assessed using modified components of short physical performance battery test. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS Version 25.0). Results: Overall 47 women were vitamin D deficient; 3 had none 22 had one 65 had two and 10 had all three adverse body composition indicators (osteosarcopenic obesity). Individuals without any adverse body composition indicator had higher total 25(OH) D (74.77.0nmol/L p0.004) compared to all the other groups 1 (53.03.8nmol/L); 2 (48.71.9nmol/L) and 3 (58.35.4nmol/L). The single inflection point (ROC curve) for total 25(OH)D in predicting osteosarcopenic obesity was 58.9nmol/L. Conclusion: Higher vitamin D levels were associated with lower body fat enhanced bone quality and improved functional capacity. Maintaining vitamin D levels above 58.9nmol/L may protect Malaysian postmenopausal women against the combined pathologies of bone muscle and excess fat.

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Abstract

Introduction: The optimal level of total 25(OH)D in Malaysian postmenopausal women that is necessary to ameliorate the combined effects of decreased bone mineral and muscle mass and increase in adiposity as seen in osteosarcopenic obesity is unknown. Given that these are common pathologies existing in bone muscle and excess fat-related disorders this study investigated the association between body composition functional capacity and total 25(OH)D levels. Methods: This was a cross-sectional study involving 117 postmenopausal Malaysian women aged 50-88 years. Total 25(OH)D was analysed by chemiluminescent microparticle immunoassay CMIA on Siemens platforms. Bone mineral was measured by broadband ultrasound attenuation. Functional performance was assessed using modified components of short physical performance battery test. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS Version 25.0). Results: Overall 47 women were vitamin D deficient; 3 had none 22 had one 65 had two and 10 had all three adverse body composition indicators (osteosarcopenic obesity). Individuals without any adverse body composition indicator had higher total 25(OH) D (74.77.0nmol/L p0.004) compared to all the other groups 1 (53.03.8nmol/L); 2 (48.71.9nmol/L) and 3 (58.35.4nmol/L). The single inflection point (ROC curve) for total 25(OH)D in predicting osteosarcopenic obesity was 58.9nmol/L. Conclusion: Higher vitamin D levels were associated with lower body fat enhanced bone quality and improved functional capacity. Maintaining vitamin D levels above 58.9nmol/L may protect Malaysian postmenopausal women against the combined pathologies of bone muscle and excess fat.

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Item Type:	Article
AGROVOC Term:	Women
AGROVOC Term:	Screening tests
AGROVOC Term:	Anthropometry
AGROVOC Term:	Bones
AGROVOC Term:	Bone mineralization
AGROVOC Term:	Vitamin d
AGROVOC Term:	Muscles
AGROVOC Term:	Fats
AGROVOC Term:	Obesity
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10091

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