Inhibition of cholinesterases by water-soluble palm fruit extract

Leow Soon Sen, . and Syed Fairus, . and Ravigadevi Sambanthamurthi, . Inhibition of cholinesterases by water-soluble palm fruit extract. pp. 139-151. ISSN 2811-4701

Cholinesterase (ChE) inhibitors are used for the symptomatic treatment of Alzheimers disease and other neurological pathologies. There is interest in developing new ChE inhibitors from natural plant compounds. Water-Soluble Palm Fruit Extract (WSPFE) recovered from the aqueous oil palm vegetation liquor is rich in phenolic acids and has potential neuroprotective effects. Here we investigated the effects of WSPFE samples on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). WSPFE ethyl acetate fraction (EAF) inhibited these enzymes the most (AChE IC‚‚: 0.218 0.029 g mL“; BChE IC‚‚: 222.860 5.777 g mL“) and had the highest AChE selectivity index (SI) value (1022.294) compared to whole samples and seven individual fractions but these effects were weaker than those of the AChE selective agent donepezil hydrochloride (DH) (AChE IC‚‚: 0.013 0.001 g mL“; BChE IC‚‚: 19.820 1.415 g mL“; AChE SI: 1524.615). Fractions containing p-hydroxybenzoic acid and protocatechuic acid had the lowest AChE SI values (7.584 and 9.367 respectively) and may thus function as dual ChE inhibitors. Binary mixtures of DH and WSPFE EAF might have more potent inhibitory effects against these enzymes as well as higher BChE/AChE selectivity. Further studies to investigate the ChE inhibition potential of these WSPFE samples are warranted.

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Abstract

Cholinesterase (ChE) inhibitors are used for the symptomatic treatment of Alzheimers disease and other neurological pathologies. There is interest in developing new ChE inhibitors from natural plant compounds. Water-Soluble Palm Fruit Extract (WSPFE) recovered from the aqueous oil palm vegetation liquor is rich in phenolic acids and has potential neuroprotective effects. Here we investigated the effects of WSPFE samples on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). WSPFE ethyl acetate fraction (EAF) inhibited these enzymes the most (AChE IC‚‚: 0.218 0.029 g mL“; BChE IC‚‚: 222.860 5.777 g mL“) and had the highest AChE selectivity index (SI) value (1022.294) compared to whole samples and seven individual fractions but these effects were weaker than those of the AChE selective agent donepezil hydrochloride (DH) (AChE IC‚‚: 0.013 0.001 g mL“; BChE IC‚‚: 19.820 1.415 g mL“; AChE SI: 1524.615). Fractions containing p-hydroxybenzoic acid and protocatechuic acid had the lowest AChE SI values (7.584 and 9.367 respectively) and may thus function as dual ChE inhibitors. Binary mixtures of DH and WSPFE EAF might have more potent inhibitory effects against these enzymes as well as higher BChE/AChE selectivity. Further studies to investigate the ChE inhibition potential of these WSPFE samples are warranted.

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Item Type:	Article
AGROVOC Term:	Oil palm
AGROVOC Term:	Cholinesterase
AGROVOC Term:	Fruit extracts
AGROVOC Term:	Acetylcholinesterase
AGROVOC Term:	Inhibition
AGROVOC Term:	Phenolic content
AGROVOC Term:	Disease treatment
AGROVOC Term:	Neurological diseases
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10672

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