Palm gamma-tocotrienol supplementation suppress tumour growth and metastasis in a syngeneic mouse model of breast cancer

Shonia Subramaniam, . and Ammu Kutty Radhakrishnan, . and Jeya Seela Anandha Rao, . and Premdass Ramdas, . and Ng Mei Han, . and Methil Kannan Kutty, . and Kanga Rani Selvaduray, . Palm gamma-tocotrienol supplementation suppress tumour growth and metastasis in a syngeneic mouse model of breast cancer. pp. 368-379. ISSN 2811-4701

Gamma-tocotrienol (T3) is an isoform of vitamin E found abundantly in palm oil which is reported to possess antioxidant and anticancer activities. However the immune-modulating properties of T3 have yet to be elucidated. Breast cancer (BC) was induced in female BALB/c mice by injecting 4T1 murine mammary cancer cells into their mammary fat pads. When the tumour was palpable the animals were randomly assigned into two groups: (i) control fed twice daily with 50 L vehicle (soy oil) or (ii) experimental (fed twice daily with 50 L of 0.5 mg of T3). Results show that mice fed with T3 had reduced tumour growth and metastasis. However there are no marked changes in the percentages of peripheral blood leukocytes and cytokines production in these animals. Immunohistochemistry using antibodies to murine CD4 IL12R2 IL24 and FoxP3 on tumour sections from T3 treated mice suggested that T3 induced suppression of tumour growth and metastasis as well as reduced immunosuppression in the tumour microenvironment. It can be concluded that T3 has the potential to suppress tumour growth and metastasis in this model. Further investigation on the host immune response is possible by prolonging treatment duration against BC.

Full text available from: Official URL: http://jopr.mpob.gov.my/wp-content/uploads/2021/11...

Abstract

Gamma-tocotrienol (T3) is an isoform of vitamin E found abundantly in palm oil which is reported to possess antioxidant and anticancer activities. However the immune-modulating properties of T3 have yet to be elucidated. Breast cancer (BC) was induced in female BALB/c mice by injecting 4T1 murine mammary cancer cells into their mammary fat pads. When the tumour was palpable the animals were randomly assigned into two groups: (i) control fed twice daily with 50 L vehicle (soy oil) or (ii) experimental (fed twice daily with 50 L of 0.5 mg of T3). Results show that mice fed with T3 had reduced tumour growth and metastasis. However there are no marked changes in the percentages of peripheral blood leukocytes and cytokines production in these animals. Immunohistochemistry using antibodies to murine CD4 IL12R2 IL24 and FoxP3 on tumour sections from T3 treated mice suggested that T3 induced suppression of tumour growth and metastasis as well as reduced immunosuppression in the tumour microenvironment. It can be concluded that T3 has the potential to suppress tumour growth and metastasis in this model. Further investigation on the host immune response is possible by prolonging treatment duration against BC.

[error in script]

Item Type:	Article
AGROVOC Term:	Palm oils
AGROVOC Term:	Food supplementation
AGROVOC Term:	Tocotrienols
AGROVOC Term:	Experimental animals
AGROVOC Term:	Cancer (disease)
AGROVOC Term:	Animal tumours
AGROVOC Term:	Antioxidants
AGROVOC Term:	Disease treatment
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10685

Actions (login required)

View Item