Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development antioxidant and antibacterial activities

Nazamid Saari, . and Norazlinaliza Salim, . and Fatimah Md Yusoff, . and Mohammad Zarei, . and Noor Atikah Ab Aziz, . Jellyfish collagen hydrolysate-loaded niosome for topical application: formulation development antioxidant and antibacterial activities. pp. 1-17. ISSN 2672-7226

Vesicular carrier system niosome has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes which are composed of a mixture of non-ionic surfactants was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of 6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9 DPPH scavenging activity and 34.6 metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8). The optimized niosome might be suitable for topical application.

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Abstract

Vesicular carrier system niosome has become an attractive delivery system for active ingredients in cosmetics and pharmaceuticals. This study aims to prepare a niosome formulation containing collagen hydrolysate extracted from local jellyfish (Rhopilema hispidum) with promising antioxidant and antibacterial properties. Niosomes which are composed of a mixture of non-ionic surfactants was prepared by using coacervation and sonication techniques optimized using a D-optimal mixture experimental design (MED) to obtain a small particle size. The particle size of the niosome obtained was 111.2 nm with a polydispersity index (PDI) value of 0.256 and a zeta potential value of 6.62 mV. Transmission Electron Microscopy (TEM) study showed the formation of spherical bilayer vesicle with a size correlating well with Zetasizer analysis. The stability of the niosome formulation was studied over a 60-day period during which changes in particle size from 104.5 to 386.5 nm were observed. The results showed no phase separation or creaming. Niosome obtained from this study was shown to exhibit antioxidant (65.9 DPPH scavenging activity and 34.6 metal chelating activity) and exhibited inhibitory activity against Staphylococcus aureus (up to 98.8). The optimized niosome might be suitable for topical application.

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Item Type:	Article
AGROVOC Term:	Rhopilema hispidum
AGROVOC Term:	Collagen
AGROVOC Term:	Experimental design
AGROVOC Term:	Protein hydrolysate
AGROVOC Term:	Formulations
AGROVOC Term:	Antibacterial properties
AGROVOC Term:	Antioxidants
AGROVOC Term:	Cytotoxicity
AGROVOC Term:	Topical application
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/10699

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