Citation
Bello S. O, . and Muhammad B. Y., . and Gammaniel K. S., . and Abdu-Aguyed I., . and Ahmed H., . and Njoku C. H., . and Pindiga U. H., . and Salka A. M., . (2006) Preliminary evaluation of the acute repeat dose toxicity and some pharmacological properties of the aqueous crude extract of Solanum melongena L. [Proceedings Paper]
Abstract
The toxicity and folkloric claim of the use of Solanum melongena L SM for long term control of asthma and as a prokinetic and weight reducing agent was evaluated in whole animal and isolated tissue studies. The aqueous crude extract of SM was not toxic in Swiss albino mice LD503000mg/kg/oral but relatively toxic in Hartley guinea pigs LD50: 1098 95 CI: 550 -2000 caused loss of weight with anaemia unconjugated hyperbilirubinaemia and elevated alkaline phosphatase on repeat dose studies in New Zealand rabbits. It also revealed significant P0.05 dose dependent anti-inflammatory activity in rat albumin and cotton pellet granuloma models of inflammation but dosedependently produced an atropine and mepyramine inhibitable constriction of isolated guinea pig tracheal ring and isolated guinea pig ileum segments with EC50 of 38pg/ml and 10g/ml respectively. This study supports the folkloric use of SM for weight loss long term control of asthma and as a prokinetic agent but raises some doubt about its use for the control of acute attacks of asthma.
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Abstract
The toxicity and folkloric claim of the use of Solanum melongena L SM for long term control of asthma and as a prokinetic and weight reducing agent was evaluated in whole animal and isolated tissue studies. The aqueous crude extract of SM was not toxic in Swiss albino mice LD503000mg/kg/oral but relatively toxic in Hartley guinea pigs LD50: 1098 95 CI: 550 -2000 caused loss of weight with anaemia unconjugated hyperbilirubinaemia and elevated alkaline phosphatase on repeat dose studies in New Zealand rabbits. It also revealed significant P0.05 dose dependent anti-inflammatory activity in rat albumin and cotton pellet granuloma models of inflammation but dosedependently produced an atropine and mepyramine inhibitable constriction of isolated guinea pig tracheal ring and isolated guinea pig ileum segments with EC50 of 38pg/ml and 10g/ml respectively. This study supports the folkloric use of SM for weight loss long term control of asthma and as a prokinetic agent but raises some doubt about its use for the control of acute attacks of asthma.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. RS180 M3I61 2005 Call Number |
| AGROVOC Term: | Acute toxicity |
| AGROVOC Term: | Toxicity |
| AGROVOC Term: | Pharmacology |
| AGROVOC Term: | Crude oil |
| AGROVOC Term: | Extracts |
| AGROVOC Term: | Solanum melongena |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:14 |
| URI: | http://webagris.upm.edu.my/id/eprint/11713 |
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