Tocotrienols: recent findings and problems

Niki Etsuo, . (2007) Tocotrienols: recent findings and problems. [Proceedings Paper]

Both tocotrienolsT3 and tocopherols T act as a antioxidant but the results so far reported on the in vitro relative activites as antioxidant are consistent. We have confirmed that the reactivities of - - - and ´-T3 and T and the corresponding T isoforms toward free radicals are the same and the corresponding T3 and T exert similar effects as a radicals scavenging antioxidant. The physical effects of T3 and T on the membrane fluidity and rigidity are also similar. The mobilities within the membranes of T3 and T are similar but T3 has higher mobility between the membranes and higher rate of incorporation into the membranes than T. T3 is incorporated into cell faster then T. The cellular distribution is similar between T3 and T and it is determined by the lipid contents. T3 showed higher protective effects than the corresponding isoforms against oxidative cell damage induced by selenium deficiency primarily because of the faster rate of uptake of T3 than T into the cells. T3 also suppressed more efficiently than T the expression of adhesion molecules on endotherial cells and adhesion of monocytic cells. However this difference is due to the different celluar concentrations exerted the same effects. Nonetheless T3 exerted higher antioxidant potency than T under certain circumstances.

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Abstract

Both tocotrienolsT3 and tocopherols T act as a antioxidant but the results so far reported on the in vitro relative activites as antioxidant are consistent. We have confirmed that the reactivities of - - - and ´-T3 and T and the corresponding T isoforms toward free radicals are the same and the corresponding T3 and T exert similar effects as a radicals scavenging antioxidant. The physical effects of T3 and T on the membrane fluidity and rigidity are also similar. The mobilities within the membranes of T3 and T are similar but T3 has higher mobility between the membranes and higher rate of incorporation into the membranes than T. T3 is incorporated into cell faster then T. The cellular distribution is similar between T3 and T and it is determined by the lipid contents. T3 showed higher protective effects than the corresponding isoforms against oxidative cell damage induced by selenium deficiency primarily because of the faster rate of uptake of T3 than T into the cells. T3 also suppressed more efficiently than T the expression of adhesion molecules on endotherial cells and adhesion of monocytic cells. However this difference is due to the different celluar concentrations exerted the same effects. Nonetheless T3 exerted higher antioxidant potency than T under certain circumstances.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP684 P3I61 2007 Call Number
AGROVOC Term:	Tocotrienols
AGROVOC Term:	Tocopherols
AGROVOC Term:	Antioxidants
AGROVOC Term:	In vitro
AGROVOC Term:	Lipid content
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:14
URI:	http://webagris.upm.edu.my/id/eprint/11730

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