Citation
Libinaki, Roksan and Negis, Yesim and Özer, Nesrin and Azzi, Angelo and Zingg, Jean-Marc and Aytan, Nurgül and Gianello, Robert and Ogru, Esra (2005) The effects of tocopherol phosphates on atherosclerosis. [Proceedings Paper]
Abstract
RRR-a-Tocopherol has been long regarded the most active form of vitamin E. Compared to the other forms of vitamin E, (B, Y, 8-tocopherols and tocotrienols), a-tocopherol is present in the circulation in greater amounts due to its less rapid degradation in the body and by being overall better retained in the body [1,2]. Recently, novel derivatives of tocopherol have been described, namely a-tocopheryl phosphate and di-a-tocopheryl phosphate [3,4]. The former compound is the ester derivative of phosphate with the hydroxyl group of tocopherol, whereas the latter is obtained by the esterification of two tocopherol moieties with one phosphate molecule. Given the important effects of a-tocopherol on cells involved in atherosclerosis and inflammation, a mixture of tocopheryl phosphate (TPM) has been formulated and tested for its ability to regulate cell proliferation, regulation of CD36 and uptake of oxidized LDL and reduce plaque formation. The data suggests that TPm is not only able to mimic the effects of a-tocopherol but appears more effective at lower concentrations.
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Abstract
RRR-a-Tocopherol has been long regarded the most active form of vitamin E. Compared to the other forms of vitamin E, (B, Y, 8-tocopherols and tocotrienols), a-tocopherol is present in the circulation in greater amounts due to its less rapid degradation in the body and by being overall better retained in the body [1,2]. Recently, novel derivatives of tocopherol have been described, namely a-tocopheryl phosphate and di-a-tocopheryl phosphate [3,4]. The former compound is the ester derivative of phosphate with the hydroxyl group of tocopherol, whereas the latter is obtained by the esterification of two tocopherol moieties with one phosphate molecule. Given the important effects of a-tocopherol on cells involved in atherosclerosis and inflammation, a mixture of tocopheryl phosphate (TPM) has been formulated and tested for its ability to regulate cell proliferation, regulation of CD36 and uptake of oxidized LDL and reduce plaque formation. The data suggests that TPm is not only able to mimic the effects of a-tocopherol but appears more effective at lower concentrations.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. TP684 P3I61 2005 Call Number |
| AGROVOC Term: | tocopherols |
| AGROVOC Term: | phosphates |
| AGROVOC Term: | vitamin E |
| AGROVOC Term: | inhibition |
| AGROVOC Term: | experimentation |
| AGROVOC Term: | human health |
| AGROVOC Term: | metabolism |
| AGROVOC Term: | antioxidants |
| Geographical Term: | Australia |
| Depositing User: | Nor Hasnita Abdul Samat |
| Date Deposited: | 01 Nov 2025 11:37 |
| Last Modified: | 10 Nov 2025 01:05 |
| URI: | http://webagris.upm.edu.my/id/eprint/1225 |
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