Palm phenolics raise hdl cholesterol and plasma antioxidant status in hamsters

Balasundram, Nagendran. and Ai, Tan Yew. and Sambanthamurthi, Ravigadevi. and Sundram, Kalyana. and Samman, Samir. (2005) Palm phenolics raise hdl cholesterol and plasma antioxidant status in hamsters. [Proceedings Paper]

The phenolic-rich extracts from palm fruits have been found to exhibit potent in vitro antioxidant activity, inhibiting Fe/H2O2/ascorbic acid-induced oxidation in a liposome model system in a dose dependent manner. These extracts were also found to protect against oxidation of human erythrocytes and haemoglobin in ex vivo systems. The objective of this study was to investigate the effects of phenolic-rich palm fruit juice (PFJ) on plasma lipid profile and antioxidant status of golden Syrian hamsters (Mesocricetus auratus) fed a high-fat, high-cholesterol (1.5g/kg) atherogenic diet. In this study, 4-wk old male hamsters were assigned randomly into four groups and fed the atherogenic diet for 8 wk. Hamsters in three of the treatment groups were provided, as drinking fluid, PFJ at 3 different phenolic concentrations, i.e. 500, 1000, or 1500 mg gallic acid equivalents (GAE)/L, while the Control group was provided with water. Feed and fluid were provided ad libitum. Plasma total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were significantly elevated in hamsters given PFJ containing 1500 mg GAE/L phenolics compared to the Control and the other two treatment groups. However, plasma triglycerides (TG) and non-HDL-C levels remained unaffected by the treatments. The plasma antioxidant capacity as measured by the ferric-reducing ability of plasma (FRAP) method was found to increase in hamsters given PFJ at the highest concentration (1500 mg GAE/L).

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Abstract

The phenolic-rich extracts from palm fruits have been found to exhibit potent in vitro antioxidant activity, inhibiting Fe/H2O2/ascorbic acid-induced oxidation in a liposome model system in a dose dependent manner. These extracts were also found to protect against oxidation of human erythrocytes and haemoglobin in ex vivo systems. The objective of this study was to investigate the effects of phenolic-rich palm fruit juice (PFJ) on plasma lipid profile and antioxidant status of golden Syrian hamsters (Mesocricetus auratus) fed a high-fat, high-cholesterol (1.5g/kg) atherogenic diet. In this study, 4-wk old male hamsters were assigned randomly into four groups and fed the atherogenic diet for 8 wk. Hamsters in three of the treatment groups were provided, as drinking fluid, PFJ at 3 different phenolic concentrations, i.e. 500, 1000, or 1500 mg gallic acid equivalents (GAE)/L, while the Control group was provided with water. Feed and fluid were provided ad libitum. Plasma total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were significantly elevated in hamsters given PFJ containing 1500 mg GAE/L phenolics compared to the Control and the other two treatment groups. However, plasma triglycerides (TG) and non-HDL-C levels remained unaffected by the treatments. The plasma antioxidant capacity as measured by the ferric-reducing ability of plasma (FRAP) method was found to increase in hamsters given PFJ at the highest concentration (1500 mg GAE/L).

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. TP684 P3I61 2005 Call Number
AGROVOC Term:	palm oils
AGROVOC Term:	antioxidant
AGROVOC Term:	phenolic compounds
AGROVOC Term:	blood plasma
AGROVOC Term:	analysis
AGROVOC Term:	statistical methods
AGROVOC Term:	fruit extracts
AGROVOC Term:	cardiovascular system
Geographical Term:	Australia
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	02 Nov 2025 02:50
Last Modified:	10 Nov 2025 01:10
URI:	http://webagris.upm.edu.my/id/eprint/1233

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