Citation
Sharipah Ruzaina Syed Aris, . and Siti Sarah Syed Mohd Razali, . and Mohd Tajuddin Mohd Ali, . and Dzulsuhaimi Daud, . and Norizan Ahmat A. H., . (2008) Hypoglicemic properties of Momordica charantia methanol extract in alloxan-induced diabetic rats. [Proceedings Paper]
Abstract
Methanol extract of the Momordica charantia fruits was tested for its hypoglycemic activity. Diabetes mellitus was induced with alloxan 120 mg kg- b.w and the extracts 100 mg kg- b.w were orally administered daily for 14days to alloxan-induced diabetic rats. Daily administration of the methanol extract of M. charantia reduced the blood glucose levels significantly p 0.05 in treated rats compared to control. In addition the treated rats showed significant increase in their body weight following treatment. These results suggested that Momordica charantia fruits possess an antidiabetic principle and can be used for treatment of diabetes. Further studies are warranted to fractionate the active principle and to find out its exact mechanism of action.
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Abstract
Methanol extract of the Momordica charantia fruits was tested for its hypoglycemic activity. Diabetes mellitus was induced with alloxan 120 mg kg- b.w and the extracts 100 mg kg- b.w were orally administered daily for 14days to alloxan-induced diabetic rats. Daily administration of the methanol extract of M. charantia reduced the blood glucose levels significantly p 0.05 in treated rats compared to control. In addition the treated rats showed significant increase in their body weight following treatment. These results suggested that Momordica charantia fruits possess an antidiabetic principle and can be used for treatment of diabetes. Further studies are warranted to fractionate the active principle and to find out its exact mechanism of action.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Uni-versiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal RM666 H33 B573 Call Number |
| AGROVOC Term: | Momordica charantia |
| AGROVOC Term: | Drug plants |
| AGROVOC Term: | Hyperglycaemia |
| AGROVOC Term: | Blood sugar |
| AGROVOC Term: | Diabetes mellitus |
| AGROVOC Term: | Methanol |
| AGROVOC Term: | Fruits |
| AGROVOC Term: | Extraction |
| AGROVOC Term: | Filtering |
| AGROVOC Term: | Body weight |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/12850 |
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