Citation
Faridah H., . and Asmah R., . and Fauziah O., . and Norfarizan Hanoon N. A., . and Rokiah M. Y., . (2008) Effects of Strobilanthes crispus juice on antioxidant enzymes and wound healing in normal and streptozotocin-induced diabetic rats. [Proceedings Paper]
Abstract
In diabetes impaired glucose metabolism may lead to an increase in hydroxyl radical production. Free radicals may also be formed via the auto-oxidation of unsaturated lipids in plasma and membrane lipids. The free radicals produced may react with polyunsaturated fatty acids in cell membranes leading to lipid peroxidation. the level of lipid peroxidation in cells is controlled by various cellular defense mechanisms consisting of enzymatic and nonezymatic scavenger systems. The levels of these defense mechanisms are altered in diabetes and therefore the ineffective scavenging of free radicals plays a crucial role in determining tissue injury. the objective of this study is to determine the effect of strobilanthes crispus S. crispus juice on antioxidative enzymes activity and wound healing in normal and streptozotocin-induced rats. a total of 48 male albino sprague dawley rats. weight 150-200 g were used. the rats were divided into 8 groups with 6 rats in each group. the healing of 2 cm linear incisions created on the back of each rat was monitored by measuring the length of the wounds daily. The result showed a significant increase p 0.05 in the percentage of wound healing at day 3 and 7 in the treated group especially treated with 1.0 ml/kg b.w.of S. crispus juice in diabetic and normal rats compared with the control. S. crispus juice increased significantly p 0.05 of glutathione peroxidase and significant decrease of superoxide dismutase activity in treated group in diabetic rats. Significant correlation was found between wound healing GPx and SOD enzymes. In conclusion S. crispus juice enhances wound healing in normal and diabetic rats.
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Abstract
In diabetes impaired glucose metabolism may lead to an increase in hydroxyl radical production. Free radicals may also be formed via the auto-oxidation of unsaturated lipids in plasma and membrane lipids. The free radicals produced may react with polyunsaturated fatty acids in cell membranes leading to lipid peroxidation. the level of lipid peroxidation in cells is controlled by various cellular defense mechanisms consisting of enzymatic and nonezymatic scavenger systems. The levels of these defense mechanisms are altered in diabetes and therefore the ineffective scavenging of free radicals plays a crucial role in determining tissue injury. the objective of this study is to determine the effect of strobilanthes crispus S. crispus juice on antioxidative enzymes activity and wound healing in normal and streptozotocin-induced rats. a total of 48 male albino sprague dawley rats. weight 150-200 g were used. the rats were divided into 8 groups with 6 rats in each group. the healing of 2 cm linear incisions created on the back of each rat was monitored by measuring the length of the wounds daily. The result showed a significant increase p 0.05 in the percentage of wound healing at day 3 and 7 in the treated group especially treated with 1.0 ml/kg b.w.of S. crispus juice in diabetic and normal rats compared with the control. S. crispus juice increased significantly p 0.05 of glutathione peroxidase and significant decrease of superoxide dismutase activity in treated group in diabetic rats. Significant correlation was found between wound healing GPx and SOD enzymes. In conclusion S. crispus juice enhances wound healing in normal and diabetic rats.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Uni-versiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. mal RM666 H33 B573 Call Number |
| AGROVOC Term: | Acanthaceae |
| AGROVOC Term: | Medicinal plants |
| AGROVOC Term: | Antioxidants |
| AGROVOC Term: | Diabetes |
| AGROVOC Term: | Wounds |
| AGROVOC Term: | Enzyme activity |
| AGROVOC Term: | Enzymes |
| AGROVOC Term: | Leaves |
| AGROVOC Term: | Experimental animals |
| AGROVOC Term: | Experimental design |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:15 |
| URI: | http://webagris.upm.edu.my/id/eprint/12867 |
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