Anti-proliferative activity of Zingiberaceae methanol extract on MDA-MB-231 human breast cancer cells

Nurhayati Z. A., . and Yap V. A., . and Norhanom A. W., . (2010) Anti-proliferative activity of Zingiberaceae methanol extract on MDA-MB-231 human breast cancer cells. [Proceedings Paper]

Breast cancer has been and still is the leading cause of death among women both locally and worldwide. The lack of cure for this has encouraged the search for anticancer treatments in natural products. Species of the Zingiberaceae family have long been utilized for both culinary and medicinal use and therefore has made them potential candidates in the search for new chemotherapeutic agents. In this study methanolic extracts of five selected Zingiberaceae species namely Curcuma domestica Languas galanga Zingiber zerumbet Zingiber officinale and Zingiber montanum were investigated for possible anti-proliferative activity using MTT assay against human breast cancer MDA-MB-231 cell line. The cells were treated with crude methanol extracts at different concentrations ranging from 1 g/ml to 100 g/ml for 72 hours. All extracts showed dose-dependant anti-proliferative activity but at different intensities Out of the five species tested three of the methanolic extracts namely L. galanga C. domestica and Z. zerumbet exhibited good anti-proliferative activities against MDA-MB-231 cells with ED‚‚ values of 4.7 g/ml 7.2 g/ml and 10.5 g/ml respectively. ED‚‚ denotes the concentration of extract that inhibits the growth of 50 of the cells. Crude extracts that give ED‚‚ values lesser than or equal to 20 g/ml is considered active. Thus these findings suggest that Zingerbers have potential in the role of tumor chemoprevention or as a potential tumor therapeutic agent.

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Abstract

Breast cancer has been and still is the leading cause of death among women both locally and worldwide. The lack of cure for this has encouraged the search for anticancer treatments in natural products. Species of the Zingiberaceae family have long been utilized for both culinary and medicinal use and therefore has made them potential candidates in the search for new chemotherapeutic agents. In this study methanolic extracts of five selected Zingiberaceae species namely Curcuma domestica Languas galanga Zingiber zerumbet Zingiber officinale and Zingiber montanum were investigated for possible anti-proliferative activity using MTT assay against human breast cancer MDA-MB-231 cell line. The cells were treated with crude methanol extracts at different concentrations ranging from 1 g/ml to 100 g/ml for 72 hours. All extracts showed dose-dependant anti-proliferative activity but at different intensities Out of the five species tested three of the methanolic extracts namely L. galanga C. domestica and Z. zerumbet exhibited good anti-proliferative activities against MDA-MB-231 cells with ED‚‚ values of 4.7 g/ml 7.2 g/ml and 10.5 g/ml respectively. ED‚‚ denotes the concentration of extract that inhibits the growth of 50 of the cells. Crude extracts that give ED‚‚ values lesser than or equal to 20 g/ml is considered active. Thus these findings suggest that Zingerbers have potential in the role of tumor chemoprevention or as a potential tumor therapeutic agent.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. TP248.14 I61 2008 Call Number.
AGROVOC Term:	Zingiberaceae
AGROVOC Term:	Languas
AGROVOC Term:	Curcuma domestica
AGROVOC Term:	Zingiber
AGROVOC Term:	Zingiber officinale
AGROVOC Term:	Extraction in chemical analysis
AGROVOC Term:	Methanol
AGROVOC Term:	Plant extracts
AGROVOC Term:	Breasts
AGROVOC Term:	Disease treatment
Geographical Term:	MALAYSIA
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 05:15
URI:	http://webagris.upm.edu.my/id/eprint/13158

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