Antimicrobial peptides: design, chemical synthesis, activity evaluation, and application

Yang, H. and Wang, L. and Du, H. and Zhao, D. and Liu, C. and Lu, K. (2023) Antimicrobial peptides: design, chemical synthesis, activity evaluation, and application. International Food Research Journal (Malaysia), 30. pp. 814-831. ISSN 2231 7546

Antimicrobial peptides (AMPs) are active short peptides that exist in microorganisms, insects, amphibians, plants, and mammals. Some naturally occurring AMPs have low antimicrobial activity, high haemolysis, potential toxicity toward mammalian cells, and high susceptibility to proteolytic degradation, which limit their practical application. In recent years, many efforts have been made to design and modify AMPs to improve their properties. The present review focuses on site-directed mutation, truncation, hybridisation, capping, and cyclisation of AMPs. The review further introduces the application of solidphase peptide synthesis technology for AMPs, and summarises the methods for evaluating the antimicrobial activity of AMPs. The in-depth research on AMPs is expected to play an essential role in the fields of agriculture, animal husbandry, food industry, and medicine.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/30%20(04)%202023/01%20-...

Abstract

Antimicrobial peptides (AMPs) are active short peptides that exist in microorganisms, insects, amphibians, plants, and mammals. Some naturally occurring AMPs have low antimicrobial activity, high haemolysis, potential toxicity toward mammalian cells, and high susceptibility to proteolytic degradation, which limit their practical application. In recent years, many efforts have been made to design and modify AMPs to improve their properties. The present review focuses on site-directed mutation, truncation, hybridisation, capping, and cyclisation of AMPs. The review further introduces the application of solidphase peptide synthesis technology for AMPs, and summarises the methods for evaluating the antimicrobial activity of AMPs. The in-depth research on AMPs is expected to play an essential role in the fields of agriculture, animal husbandry, food industry, and medicine.

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Item Type:	Article
AGROVOC Term:	peptides
AGROVOC Term:	bioactive compounds
AGROVOC Term:	bactericides
AGROVOC Term:	fungicides
AGROVOC Term:	chemical synthesis
AGROVOC Term:	analysis
AGROVOC Term:	microorganisms
AGROVOC Term:	biochemists
AGROVOC Term:	pathogenic bacteria
AGROVOC Term:	antimicrobial resistance
Geographical Term:	China
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	10 Nov 2025 02:44
Last Modified:	10 Nov 2025 02:44
URI:	http://webagris.upm.edu.my/id/eprint/1337

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