Citation
Siti Kamariah H., . and Fauziah A., . and Hani Idayu B., . and Saidatul Husni S., . and Fadzureena J., . and Nor Azah M. A., . (2013) Active ingredient for herbal product from Tetracera maingayi. [Proceedings Paper]
Abstract
Tetracera maingayi Dilleniaceae is an evergreen woody climber. To date there is no report on the traditional uses and very little information is available on the phytochemical and pharmacological properties of extracts or purified compounds from T. maingayi. Our preliminary studies indicated that the extract of T. maingayi exhibited significant anti-inflammatory activities via hyaluronidase assay. Hyaluronidase is an enzyme that degrades hyaluronic acid HA. HA acts as a promoter of early inflammation which is crucial in the whole skin wound-healing process. Therefore a systematic approach was carried out to obtain active anti-inflammatory extract from this plant. Effect of extraction parameters such as temperature extraction time and solvent ratio as well as their anti-inflammatory properties via respective assay was investigated. The anti-inflammatory active extract was formulated into active ingredient namely as TM2011 and was found to be stable without any changes of colour or separation of phase after being stored at 4 room temperature and 40C for three months. TM2011 also found significantly inhibited hyaluronidase enzyme activity at 92 in test concentration of 100ug/ml and was tested for several topical personal care formulation such as cream and lotion. These topical products formulated with TM2011 are recommended for restoring skin health after inflammation process.
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Abstract
Tetracera maingayi Dilleniaceae is an evergreen woody climber. To date there is no report on the traditional uses and very little information is available on the phytochemical and pharmacological properties of extracts or purified compounds from T. maingayi. Our preliminary studies indicated that the extract of T. maingayi exhibited significant anti-inflammatory activities via hyaluronidase assay. Hyaluronidase is an enzyme that degrades hyaluronic acid HA. HA acts as a promoter of early inflammation which is crucial in the whole skin wound-healing process. Therefore a systematic approach was carried out to obtain active anti-inflammatory extract from this plant. Effect of extraction parameters such as temperature extraction time and solvent ratio as well as their anti-inflammatory properties via respective assay was investigated. The anti-inflammatory active extract was formulated into active ingredient namely as TM2011 and was found to be stable without any changes of colour or separation of phase after being stored at 4 room temperature and 40C for three months. TM2011 also found significantly inhibited hyaluronidase enzyme activity at 92 in test concentration of 100ug/ml and was tested for several topical personal care formulation such as cream and lotion. These topical products formulated with TM2011 are recommended for restoring skin health after inflammation process.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QK99 M3S471 2012 Call Number. |
| AGROVOC Term: | Dilleniaceae |
| AGROVOC Term: | Climbers |
| AGROVOC Term: | Herbs herbaceous plants |
| AGROVOC Term: | Extraction in chemical analysis |
| AGROVOC Term: | Plant extracts |
| AGROVOC Term: | Antiinflammatory agents |
| AGROVOC Term: | Product development |
| AGROVOC Term: | Formulations |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 24 Apr 2025 05:16 |
| URI: | http://webagris.upm.edu.my/id/eprint/13716 |
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