Effect of petai Parkia speciosa Hassk. on blood glucose level in rats

Goh S.K., . and Hamdan N., . (2000) Effect of petai Parkia speciosa Hassk. on blood glucose level in rats. [Proceedings Paper]

The hypoglycaemic effect of the water extracts from seeds of Petai Parkia speciosa Hassk. on blood glucose levels of normal rats was studied. The extracts were prepared by Soxhlet extraction and freeze-dried to obtain concentrated solid product. Oral Glucose Tolerance Test was performed by oral administration of 1.5 g/kg b.w. body weight of glucose load and four treatment doses 50 100 200 and 400 mg/kg b.w. of the extract. Saline and glibenclamide were used as controls. Blood samples were taken at -30 0 5 15 30 60 90 120 150 180 and 210 minutes and the blood glucose concentration was determined by the glucose oxidase method. The results of this study showed that dosages of 50 100 and 200 mg/kg b.w. had no effect in reducing the blood glucose levels. The dosage of 400 mg/kg b.w. had a significant effect in reducing blood glucose level in experimental rats. However the effect of the water extract was less pronounced compared to the established hypoglycaemic agent glibenclamide.

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Abstract

The hypoglycaemic effect of the water extracts from seeds of Petai Parkia speciosa Hassk. on blood glucose levels of normal rats was studied. The extracts were prepared by Soxhlet extraction and freeze-dried to obtain concentrated solid product. Oral Glucose Tolerance Test was performed by oral administration of 1.5 g/kg b.w. body weight of glucose load and four treatment doses 50 100 200 and 400 mg/kg b.w. of the extract. Saline and glibenclamide were used as controls. Blood samples were taken at -30 0 5 15 30 60 90 120 150 180 and 210 minutes and the blood glucose concentration was determined by the glucose oxidase method. The results of this study showed that dosages of 50 100 and 200 mg/kg b.w. had no effect in reducing the blood glucose levels. The dosage of 400 mg/kg b.w. had a significant effect in reducing blood glucose level in experimental rats. However the effect of the water extract was less pronounced compared to the established hypoglycaemic agent glibenclamide.

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Item Type:	Proceedings Paper
Additional Information:	Available at Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. RS164 S471 1999 Call Number
AGROVOC Term:	PARKIA
AGROVOC Term:	DRUG PLANTS
AGROVOC Term:	MEDICINAL PROPERTIES
AGROVOC Term:	TRADITIONAL MEDICINES
AGROVOC Term:	SEED EXTRACTS
AGROVOC Term:	BLOOD SUGAR
AGROVOC Term:	ORAL ADMINISTRATION
AGROVOC Term:	SALINITY CONTROL
AGROVOC Term:	HYPOGLYCAEMIA
AGROVOC Term:	CARBOHYDRATES
Geographical Term:	MALAYSIA
Depositing User:	Ms. Norfaezah Khomsan
Last Modified:	24 Apr 2025 05:27
URI:	http://webagris.upm.edu.my/id/eprint/15896

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