Citation
Rasadah Mat Ali, . and Houghton P.J., . (2001) Lipoxygenase inhibitors from Fernandoa adenophylla Wall.ex.g.don Steen. [Proceedings Paper]
Abstract
Two types of in vitro screening methods i.e. inhibition of soybean 5-lipoxygenase and inhibition of TXB2 and LTB4 production from arachidonate have been used to indicate possible in vitro anti-inflammatory activity of Fernandoa adenophylla. It was found that the root and stembark of F. adenophylla showed significant inhibitory activity against 5-soya lipoxygenase. Root of F. adenophylla showed strong inhibitory acivity against soybean lipoxygenase and LTB4 production. The most active compound from F. adenophylla root was the naphthoquinone lapachol while the flavonoids pinocembrin and chrysin showed appreciable anti-inflammatory activity.
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Abstract
Two types of in vitro screening methods i.e. inhibition of soybean 5-lipoxygenase and inhibition of TXB2 and LTB4 production from arachidonate have been used to indicate possible in vitro anti-inflammatory activity of Fernandoa adenophylla. It was found that the root and stembark of F. adenophylla showed significant inhibitory activity against 5-soya lipoxygenase. Root of F. adenophylla showed strong inhibitory acivity against soybean lipoxygenase and LTB4 production. The most active compound from F. adenophylla root was the naphthoquinone lapachol while the flavonoids pinocembrin and chrysin showed appreciable anti-inflammatory activity.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QD415 A1N277 2000 |
| AGROVOC Term: | BIGNONIACEAE |
| AGROVOC Term: | SOYBEANS |
| AGROVOC Term: | LIPOXYGENASE |
| AGROVOC Term: | TRADITIONAL MEDICINES |
| AGROVOC Term: | ANTIINFLAMMATORY AGENTS |
| AGROVOC Term: | STEMS |
| AGROVOC Term: | ROOTS |
| AGROVOC Term: | EXTRACTS |
| AGROVOC Term: | ISOLATION |
| AGROVOC Term: | RATS |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Norfaezah Khomsan |
| Last Modified: | 24 Apr 2025 05:27 |
| URI: | http://webagris.upm.edu.my/id/eprint/15926 |
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