Citation
Rabeta Mohd Salleh, . and Asmah Rahmat, . and Nawalyah Abd. Ghani, . and Siti Muskinah Mansor, . (2001) Effect of fresh garlic on glutathione and liver tumor-marker enzyme activities in rats induced with hepatocarcinogen. [Proceedings Paper]
Abstract
Over the past half century experiments on laboratory animals and more recently studies in human populations have generated on abundant data pertaining to the role of dietary components in the etiology and prevention of cancer. For example previous studies have used bioactive compounds in garlic as anti-cancer agent. The objective of this study is to determine the effect of 4 different doses of fresh galic in rats treated with diethylnitrosamine DEN and 2-acetylaminofluorene AAF as promoters of liver cancer in vivo by determining the glutathione GSH level and tumor-marker enzyme activities in the liver such as glutathione S-transferase GST and uridine diphosphoglucuronyl transferase UDPGT. The GST result showed no significant differrence between control and low dose of garlic 50 mg/kg body weight group whereas high doses of garlic 100 mg/kg body weight. In conclusion most of the doses of garlic caused the decreases of GST and UDPGT activities and also the concentration of GSH. The optimum dose of the garlic to decrease the severity of hepatocarcinogenesis seems to be 50 mg/kg body weight.
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Abstract
Over the past half century experiments on laboratory animals and more recently studies in human populations have generated on abundant data pertaining to the role of dietary components in the etiology and prevention of cancer. For example previous studies have used bioactive compounds in garlic as anti-cancer agent. The objective of this study is to determine the effect of 4 different doses of fresh galic in rats treated with diethylnitrosamine DEN and 2-acetylaminofluorene AAF as promoters of liver cancer in vivo by determining the glutathione GSH level and tumor-marker enzyme activities in the liver such as glutathione S-transferase GST and uridine diphosphoglucuronyl transferase UDPGT. The GST result showed no significant differrence between control and low dose of garlic 50 mg/kg body weight group whereas high doses of garlic 100 mg/kg body weight. In conclusion most of the doses of garlic caused the decreases of GST and UDPGT activities and also the concentration of GSH. The optimum dose of the garlic to decrease the severity of hepatocarcinogenesis seems to be 50 mg/kg body weight.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QD415 A1N277 2000 |
| AGROVOC Term: | GARLIC |
| AGROVOC Term: | RATS |
| AGROVOC Term: | GLUTATHIONE |
| AGROVOC Term: | LIVER DISEASES |
| AGROVOC Term: | LIVER |
| AGROVOC Term: | ENZYME ACTIVITY |
| AGROVOC Term: | HEALTH |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Norfaezah Khomsan |
| Last Modified: | 24 Apr 2025 05:27 |
| URI: | http://webagris.upm.edu.my/id/eprint/15932 |
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