Citation
Choo C.Y., . and Nah B.K., . and Ibrahim P, . and Chan K.L., . (2001) Antimicrobial activity of Eurycoma longifolia Jack. [Proceedings Paper]
Abstract
The hexane chloroform n-butanol and aqueous exrtracts derived from a methanolic-soluble residue of Eurycoma longifolia Jack were evaluated for antimicrobial activities using the agar diffusion method. The organisms tested were Staphylococcus aureus Bacillus cereus Escherichia coli Pseudomonas aeruginosa and Candida albicans. The results obtained showed that only the hexane and chloroform extracts were active especially against B. cereus. Through bioactivity-guided fractionation of the chloroform extract 9-methoxycanthin-6-one was isolated whose structure was confirmed by IR MS and NMR spectroscopies. The compound was produced a minimum inhibitory concentration of 9 microgram mL-1 against B. cereus following the broth dilution method. Two quassinoids eurycomalactone and 14 15 beta-dihydroxyklaineanone which were concurrently isolated with the alkaloid displayed no activity against B. cereus.
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Abstract
The hexane chloroform n-butanol and aqueous exrtracts derived from a methanolic-soluble residue of Eurycoma longifolia Jack were evaluated for antimicrobial activities using the agar diffusion method. The organisms tested were Staphylococcus aureus Bacillus cereus Escherichia coli Pseudomonas aeruginosa and Candida albicans. The results obtained showed that only the hexane and chloroform extracts were active especially against B. cereus. Through bioactivity-guided fractionation of the chloroform extract 9-methoxycanthin-6-one was isolated whose structure was confirmed by IR MS and NMR spectroscopies. The compound was produced a minimum inhibitory concentration of 9 microgram mL-1 against B. cereus following the broth dilution method. Two quassinoids eurycomalactone and 14 15 beta-dihydroxyklaineanone which were concurrently isolated with the alkaloid displayed no activity against B. cereus.
Additional Metadata
| Item Type: | Proceedings Paper |
|---|---|
| Additional Information: | Perpustakaan Sultan Abdul Samad Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia. QD415 A1N277 2000 |
| AGROVOC Term: | SIMAROUBACEAE |
| AGROVOC Term: | ANTIMICROBIAL PROPERTIES |
| AGROVOC Term: | DRUG PLANTS |
| AGROVOC Term: | NMR SPECTROSCOPY |
| AGROVOC Term: | INFRARED RADIATION |
| AGROVOC Term: | EXTRACTS |
| AGROVOC Term: | MICROORGANISMS |
| AGROVOC Term: | MALAYSIA |
| Geographical Term: | MALAYSIA |
| Depositing User: | Ms. Norfaezah Khomsan |
| Last Modified: | 24 Apr 2025 05:27 |
| URI: | http://webagris.upm.edu.my/id/eprint/15952 |
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