Citation
Hassan Yaacob, . and Shahimi M.M., . and Kim K.H., . Evaluation of antinoceptive activity of the water soluble extract of sea cucumber Malaysia. pp. 23-28. ISSN 0126-8643
Abstract
The antinoceptive activity of the water extract of sea cucumber (SCE) was evaluated in mice using writhings hot tail-flick and cold tail-flick techniques in comparison to morphine and paracetamol. Whilst the control group and group treated with paracetamol exhibited no significant effect SCE (100 mg/kg) and morphine (5 mg/kg) reduced acetic acid-induced writhings from 17.5 - 2.8 counts to 4.1 - 1.5 and 7.3 - 0.6 counts respectively. All three drugs produced significant analgesia when tested by the hot tail-flick. Morphine produced peak maximum possible analgesia (MPA) of 35.1 - 4.8 while paracetamol and SCE produced MPA values of 27.8 - 2.1 and 42.2 - 4.2 respectively. When tested on cold tail-flick paracetamol did not exhibit significant antinoceptive activity whilst morphine and SCE exhibited significant antinoceptive activity with the peak MPA values of 66.2 - 2.4 and 36.1 - 9.5 respectively. The present data confirm our previous observations and suggest that SCE may possess analgesic activity beyond the reach of non-steroidal anti-inflammatory analgesic but of comparable efficacy to those opioid analgesic
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Abstract
The antinoceptive activity of the water extract of sea cucumber (SCE) was evaluated in mice using writhings hot tail-flick and cold tail-flick techniques in comparison to morphine and paracetamol. Whilst the control group and group treated with paracetamol exhibited no significant effect SCE (100 mg/kg) and morphine (5 mg/kg) reduced acetic acid-induced writhings from 17.5 - 2.8 counts to 4.1 - 1.5 and 7.3 - 0.6 counts respectively. All three drugs produced significant analgesia when tested by the hot tail-flick. Morphine produced peak maximum possible analgesia (MPA) of 35.1 - 4.8 while paracetamol and SCE produced MPA values of 27.8 - 2.1 and 42.2 - 4.2 respectively. When tested on cold tail-flick paracetamol did not exhibit significant antinoceptive activity whilst morphine and SCE exhibited significant antinoceptive activity with the peak MPA values of 66.2 - 2.4 and 36.1 - 9.5 respectively. The present data confirm our previous observations and suggest that SCE may possess analgesic activity beyond the reach of non-steroidal anti-inflammatory analgesic but of comparable efficacy to those opioid analgesic
Additional Metadata
| Item Type: | Article |
|---|---|
| Additional Information: | Summaries (En Ms) |
| AGROVOC Term: | sea cucumbers |
| AGROVOC Term: | evaluation |
| AGROVOC Term: | analgesics |
| AGROVOC Term: | Stichopus |
| Geographical Term: | Malaysia |
| Depositing User: | Ms. Norfaezah Khomsan |
| Date Deposited: | 11 Jun 2025 13:22 |
| Last Modified: | 11 Jun 2025 13:22 |
| URI: | http://webagris.upm.edu.my/id/eprint/17029 |
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