Chitosan nanocomposites as wound healing materials: advances in processing techniques and mechanical properties

Dele-Afolabi, Temitope T. and Azmah Hanim Mohamed Arif and OjoKupoluyi, Oluwatosin J. and Atoyebi, Ebenezer Oluwatosin (2023) Chitosan nanocomposites as wound healing materials: advances in processing techniques and mechanical properties. Pertanika Journal of Science & Technology (Malaysia), 31 (1). 543 -575. ISSN 2231-8526

This review discusses the increasing potential of chitosan nanocomposites as viable materials capable of targeting these debilitating factors. This review focuses on various techniques used to process chitosan nanocomposites and their mechanical properties. Chitosan nanocomposites are regarded as highly effective antimicrobials for the treatment of chronic wounds. Chitosan nanocomposites, such as chitosan/polyethylene and oxide/silica/ciprofloxacin, demonstrate efficient antibacterial activity and exhibit no cytotoxicity against Human Foreskin Fibroblast Cell Lines (HFF2). Other studies have also showcased the capacity of chitosan nanocomposites to accelerate and improve tissue regeneration through increment in the number of fibroblast cells and angiogenesis and reduction of the inflammation phase. The layer-by-layer technique has benefits, ensuring its suitability in preparing chitosan nanocomposites for drug delivery and wound dressing applications. While the co-precipitation route requires a cross-linker to achieve stability during processing, the solution-casting route can produce stable chitosan nanocomposites without a cross-linker. By using the solution casting method, fillers such as multi-walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HTs) can be uniformly distributed in the chitosan, leading to improved mechanical properties. The antibacterial effects can be achieved with the introduction of AgNPs or ZnO. With the increasing understanding of the biological mechanisms that control these diseases, there is an influx in the introduction of novel materials into the mainstream wound care market.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/resources/files/Pe...

Abstract

This review discusses the increasing potential of chitosan nanocomposites as viable materials capable of targeting these debilitating factors. This review focuses on various techniques used to process chitosan nanocomposites and their mechanical properties. Chitosan nanocomposites are regarded as highly effective antimicrobials for the treatment of chronic wounds. Chitosan nanocomposites, such as chitosan/polyethylene and oxide/silica/ciprofloxacin, demonstrate efficient antibacterial activity and exhibit no cytotoxicity against Human Foreskin Fibroblast Cell Lines (HFF2). Other studies have also showcased the capacity of chitosan nanocomposites to accelerate and improve tissue regeneration through increment in the number of fibroblast cells and angiogenesis and reduction of the inflammation phase. The layer-by-layer technique has benefits, ensuring its suitability in preparing chitosan nanocomposites for drug delivery and wound dressing applications. While the co-precipitation route requires a cross-linker to achieve stability during processing, the solution-casting route can produce stable chitosan nanocomposites without a cross-linker. By using the solution casting method, fillers such as multi-walled carbon nanotubes (MWCNTs) and halloysite nanotubes (HTs) can be uniformly distributed in the chitosan, leading to improved mechanical properties. The antibacterial effects can be achieved with the introduction of AgNPs or ZnO. With the increasing understanding of the biological mechanisms that control these diseases, there is an influx in the introduction of novel materials into the mainstream wound care market.

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Item Type:	Article
AGROVOC Term:	chitosan
AGROVOC Term:	nanocomposites
AGROVOC Term:	mechanical properties
AGROVOC Term:	antimicrobial properties
AGROVOC Term:	fabrication
AGROVOC Term:	medicinal properties
AGROVOC Term:	tissue analysis
AGROVOC Term:	medical sciences
AGROVOC Term:	wounds
AGROVOC Term:	healing
Geographical Term:	Malaysia
Uncontrolled Keywords:	Chitosan nanocomposite, mechanical properties, processing techniques, tissue regeneration, wound healing
Depositing User:	Ms. Azariah Hashim
Date Deposited:	27 Jan 2025 01:36
Last Modified:	27 Jan 2025 02:25
URI:	http://webagris.upm.edu.my/id/eprint/1870

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