Topical application of Terminalia chebula extract helps croton oil-induced dermatitis in mice

Kettawan A., . and Sukakul T., . and Chompoopong S., . and Rungruang T., . Topical application of Terminalia chebula extract helps croton oil-induced dermatitis in mice. pp. 2269-2272. ISSN 22317546

Numerous herbs have been used successfully in treating dermatologic disorders for thousands years and still widely used because it is easy to find cheap and to avoid the side effects and complications of topical steroids. Terminalia chebula commonly found in India and Southeast Asia is thought to be effective for treating several diseases including inflammation and reported as an anti-oxidant. T. chebula extract was tested on croton oil-induced ear dermatitis. The anti-inflammatory response was evaluated by observing redness ear thickness and ear plug weight. The analysis showed significantly different thickness at the time of 30 minutes till the end at 5 hours of experiment. Ear plug weight also showed significant difference between treated and untreated ears. Topical application of T. chebula extract on croton oil-induced mouse ear dermatitis can help reducing inflammation and could be a novel topical anti-inflammatory drug candidate.

Full text available from: Official URL: http://ifrj.upm.edu.my/20%20(05)%202013/30%20IFRJ%...

Abstract

Numerous herbs have been used successfully in treating dermatologic disorders for thousands years and still widely used because it is easy to find cheap and to avoid the side effects and complications of topical steroids. Terminalia chebula commonly found in India and Southeast Asia is thought to be effective for treating several diseases including inflammation and reported as an anti-oxidant. T. chebula extract was tested on croton oil-induced ear dermatitis. The anti-inflammatory response was evaluated by observing redness ear thickness and ear plug weight. The analysis showed significantly different thickness at the time of 30 minutes till the end at 5 hours of experiment. Ear plug weight also showed significant difference between treated and untreated ears. Topical application of T. chebula extract on croton oil-induced mouse ear dermatitis can help reducing inflammation and could be a novel topical anti-inflammatory drug candidate.

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Item Type:	Article
AGROVOC Term:	Topical application
AGROVOC Term:	Terminalia
AGROVOC Term:	Extracts
AGROVOC Term:	Croton
AGROVOC Term:	Mice
AGROVOC Term:	Medicinal herbs
AGROVOC Term:	Dermatology
AGROVOC Term:	Steroids
AGROVOC Term:	Inflammation
AGROVOC Term:	Natural antioxidants
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21348

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