A new latent lovastatin producer viz. Fusarium pseudocircinatum IBRL B3-4 produced in laboratory tray system


Citation

Darah I., . and Syarifah A. R., . and I Nyoman P. A., . A new latent lovastatin producer viz. Fusarium pseudocircinatum IBRL B3-4 produced in laboratory tray system. pp. 509-522.

Abstract

A proximate analysis study of local rice bran and brown rice disclosed a distinguish level of chemical compositions. Lipid carbohydrate and ash occupy in rice bran while fibre is a predominant component in brown rice. Both perceptible anti-cholesterol substrates were grown with locally isolated Fusarium pseudocircinatum IBRL B3-4 to obtain the best lovastatin activity via dichloromethane extraction. Evaluation of lovastatin production at different substrate thickness ranges of 0.25 to 1.5 cm in a static tray system (20x20x6 cm3) exposed the highest production at 0.5 cm level (1135.06.7 g/g dry solid of lovastatin). Meanwhile effects of physical parameters investigation interpreted that the original substrate size 60 (v/w) moisture content and ambient local temperature of 302C as the most suitable conditions to generate lovastatin at the utmost level. Meanwhile the maximum production was synthesized at day 12th (twelfth) under solid substrate fermentation system. A significant activity increment was revealed after 60 (v/v) moisture content had been applied into tray system. In more specific it boosted up to 2271.714.4g/g dry solid of lovastatin.


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Abstract

A proximate analysis study of local rice bran and brown rice disclosed a distinguish level of chemical compositions. Lipid carbohydrate and ash occupy in rice bran while fibre is a predominant component in brown rice. Both perceptible anti-cholesterol substrates were grown with locally isolated Fusarium pseudocircinatum IBRL B3-4 to obtain the best lovastatin activity via dichloromethane extraction. Evaluation of lovastatin production at different substrate thickness ranges of 0.25 to 1.5 cm in a static tray system (20x20x6 cm3) exposed the highest production at 0.5 cm level (1135.06.7 g/g dry solid of lovastatin). Meanwhile effects of physical parameters investigation interpreted that the original substrate size 60 (v/w) moisture content and ambient local temperature of 302C as the most suitable conditions to generate lovastatin at the utmost level. Meanwhile the maximum production was synthesized at day 12th (twelfth) under solid substrate fermentation system. A significant activity increment was revealed after 60 (v/v) moisture content had been applied into tray system. In more specific it boosted up to 2271.714.4g/g dry solid of lovastatin.

Additional Metadata

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Item Type: Article
AGROVOC Term: Fusarium
AGROVOC Term: Solid state fermentation
AGROVOC Term: Proximate analysis
AGROVOC Term: Rice
AGROVOC Term: Extraction
AGROVOC Term: Solvents
AGROVOC Term: Crude fibre
AGROVOC Term: Crude protein
AGROVOC Term: Crude fat
Geographical Term: Malaysia
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 26 Apr 2025 03:14
URI: http://webagris.upm.edu.my/id/eprint/21371

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