Phytochemical analysis, antioxidant and anticholinesterase activities of Clitoria ternatea roots extract

Nurul Zawani Alias, . and Nadzratul Aufa Mohd Faisal, . and Shafinas Abdullah, . and Syamsurina Arshad, . and Vikneswaran Murugaiyah, . and Mohamad Afiq Md Amin, . (2023) Phytochemical analysis, antioxidant and anticholinesterase activities of Clitoria ternatea roots extract. Journal of Sustainability Science and Management (Malaysia), 18 (12). pp. 1-11. ISSN 2672-7226

Clitoria ternatea is also known as ‘Bunga telang’ in Malay. The roots of C. Ternatea were traditionally used as a brain tonic to improve memory. This raises the Possibility of using the roots extract as a cholinesterase inhibitor in treating Alzheimer’s Disease symptoms. Other than cholinesterase inhibitors, its antioxidant properties would Also help in inhibiting the symptoms of Alzheimer’s disease, as oxidative stress is one of The contributing factors for this disease. Therefore, this study was conducted to identify The phytochemical constituents in C. Ternatea roots extract by using phytochemical Screening and GC-MS analysis, to evaluate the antioxidant properties of C. Ternatea roots Through DPPH radical scavenging assay and total phenolic content and also to investigate The cholinesterase inhibition potential of C. Ternatea roots extract. The phytochemical Screening revealed the presence of saponin, phenols, terpenoids and steroids. While GC-MS analysis revealed n-hexadecanoic acid as the major constituent (12.95%). The IC₅₀ Value of DPPH radical scavenging assay for the extract was 85.31g/ml and the phenolic Content in the extract was 10.84 ± 0.12 mg GAE/g. The IC₅₀ value of C. Ternatea roots Extract against ache was 118.5 ± 8.6 μg/ml and 83.59 ± 6.23 μg/ml against BChE. The Roots extract showed potential cholinesterase inhibition and antioxidant activity.

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Abstract

Clitoria ternatea is also known as ‘Bunga telang’ in Malay. The roots of C. Ternatea were traditionally used as a brain tonic to improve memory. This raises the Possibility of using the roots extract as a cholinesterase inhibitor in treating Alzheimer’s Disease symptoms. Other than cholinesterase inhibitors, its antioxidant properties would Also help in inhibiting the symptoms of Alzheimer’s disease, as oxidative stress is one of The contributing factors for this disease. Therefore, this study was conducted to identify The phytochemical constituents in C. Ternatea roots extract by using phytochemical Screening and GC-MS analysis, to evaluate the antioxidant properties of C. Ternatea roots Through DPPH radical scavenging assay and total phenolic content and also to investigate The cholinesterase inhibition potential of C. Ternatea roots extract. The phytochemical Screening revealed the presence of saponin, phenols, terpenoids and steroids. While GC-MS analysis revealed n-hexadecanoic acid as the major constituent (12.95%). The IC₅₀ Value of DPPH radical scavenging assay for the extract was 85.31g/ml and the phenolic Content in the extract was 10.84 ± 0.12 mg GAE/g. The IC₅₀ value of C. Ternatea roots Extract against ache was 118.5 ± 8.6 μg/ml and 83.59 ± 6.23 μg/ml against BChE. The Roots extract showed potential cholinesterase inhibition and antioxidant activity.

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Item Type:	Article
AGROVOC Term:	Clitoria ternatea
AGROVOC Term:	antioxidants properties
AGROVOC Term:	cholinesterase inhibitors
AGROVOC Term:	phytochemicals
AGROVOC Term:	gas chromatography
AGROVOC Term:	saponins
AGROVOC Term:	phenols
AGROVOC Term:	terpenoids
AGROVOC Term:	steroids
Geographical Term:	Malaysia
Depositing User:	Mr. Khoirul Asrimi Md Nor
Date Deposited:	28 Oct 2025 10:49
Last Modified:	28 Oct 2025 10:49
URI:	http://webagris.upm.edu.my/id/eprint/2167

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