Antidepressant activity of a polyherbal mixture in mice

El-Ashmawy I. M., . and Bayad A. E., . and Omar A. M. E., . Antidepressant activity of a polyherbal mixture in mice. pp. 2273-2277. ISSN 22317546

A polyherbal product composed of natural royal jelly Panax ginseng root Extract Clove powder Clove oil Cinnamon oil Ginger oil Nigella sativa oil and Capsicum powder have been shown to have antioxidant antistressor antianxiety and antidiabetic effects. The present study was undertaken to investigate the effect of this polyherbal mixture on depression. Swiss albino mice of either sex (20 “ 30 g) were used in this study. Five groups of mice were treated with different treatments (corn oil 10 ml/kg Xtend 70 140 280 mg/kg sertraline 5 mg/kg per os) for 30 consecutive days. Experiments were done on days 1 15 and 31 by employing two experimental models the Forced Swim Test (FST) and Tail Suspension Test (TST) to determine the effects of Xtend on duration of immobility. The results showed that Xtend in a dose dependent manner significantly reduces the duration of immobility (p 0.05) compared to control in FST and TST. However these treatments did not affect the number of crossing and rearing in the open-field test. There were no signs of acute toxicity observed for Xtend in ATS. Results obtained from the present study suggested that the polyherbal mixture Xtend exhibited antidepressant “ like effects and indicated the potential use of this polyherbal formulation as an adjuvant in the treatment of depression.

Full text available from: Official URL: http://ifrj.upm.edu.my/21%20(06)%202014/30%20IFRJ%...

Abstract

A polyherbal product composed of natural royal jelly Panax ginseng root Extract Clove powder Clove oil Cinnamon oil Ginger oil Nigella sativa oil and Capsicum powder have been shown to have antioxidant antistressor antianxiety and antidiabetic effects. The present study was undertaken to investigate the effect of this polyherbal mixture on depression. Swiss albino mice of either sex (20 “ 30 g) were used in this study. Five groups of mice were treated with different treatments (corn oil 10 ml/kg Xtend 70 140 280 mg/kg sertraline 5 mg/kg per os) for 30 consecutive days. Experiments were done on days 1 15 and 31 by employing two experimental models the Forced Swim Test (FST) and Tail Suspension Test (TST) to determine the effects of Xtend on duration of immobility. The results showed that Xtend in a dose dependent manner significantly reduces the duration of immobility (p 0.05) compared to control in FST and TST. However these treatments did not affect the number of crossing and rearing in the open-field test. There were no signs of acute toxicity observed for Xtend in ATS. Results obtained from the present study suggested that the polyherbal mixture Xtend exhibited antidepressant “ like effects and indicated the potential use of this polyherbal formulation as an adjuvant in the treatment of depression.

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Item Type:	Article
AGROVOC Term:	Herbal therapy
AGROVOC Term:	Royal jelly
AGROVOC Term:	Panax ginseng
AGROVOC Term:	Cloves
AGROVOC Term:	Cinnamon
AGROVOC Term:	Ginger
AGROVOC Term:	Nigella sativa
AGROVOC Term:	Capsicum
AGROVOC Term:	Stress
AGROVOC Term:	Mice
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/21931

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