Protective effects of pulp and kernel oils from Canarium odontophyllum fruit in normal and hypercholesterolemic rabbits

Azrina A., . and Faridah Hanim S., . and Khoo H. E., . and Amin I., . Protective effects of pulp and kernel oils from Canarium odontophyllum fruit in normal and hypercholesterolemic rabbits. pp. 1318-1326. ISSN 22317546

This study aimed to determine the protective effects of CO pulp and kernel oils supplementation to normocholesterolemic and hypercholesterolemic rabbits. Rabbits from the treatment groups were supplemented with CO pulp and kernel oils for four weeks. Bloods were drawn from all experimental groups at baseline and fourth week to determine protective effects of CO oils supplementation on plasma total antioxidant status (TAS) and catalase (CAT) activity. Liver function tests (ALT AST and GGT activities) were also determined for all the groups. The results showed that CO oil supplementation increased plasma TAS in both normal and hypercholesterolemic groups. Plasma CAT activities in the hypercholesterolemic groups supplemented with CO oils were significantly reduced but not for the normocholesterolemic groups. Significant reduction of plasma AST was observed for the hypercholesterolemic rabbits given CO pulp and kernel oils compared with the hypercholesterolemic control rabbits but not for plasma ALT and GGT. In the normocholesterolemic rabbits CO pulp oil had caused a significant elevation of plasma ALT AST and GGT levels as compared to the negative control rabbits. Therefore CO pulp and kernel oils are somehow not hepatotoxic and the oils are potent functional foods.

Full text available from: Official URL: http://ifrj.upm.edu.my/22%20(04)%202015/(1).pdf

Abstract

This study aimed to determine the protective effects of CO pulp and kernel oils supplementation to normocholesterolemic and hypercholesterolemic rabbits. Rabbits from the treatment groups were supplemented with CO pulp and kernel oils for four weeks. Bloods were drawn from all experimental groups at baseline and fourth week to determine protective effects of CO oils supplementation on plasma total antioxidant status (TAS) and catalase (CAT) activity. Liver function tests (ALT AST and GGT activities) were also determined for all the groups. The results showed that CO oil supplementation increased plasma TAS in both normal and hypercholesterolemic groups. Plasma CAT activities in the hypercholesterolemic groups supplemented with CO oils were significantly reduced but not for the normocholesterolemic groups. Significant reduction of plasma AST was observed for the hypercholesterolemic rabbits given CO pulp and kernel oils compared with the hypercholesterolemic control rabbits but not for plasma ALT and GGT. In the normocholesterolemic rabbits CO pulp oil had caused a significant elevation of plasma ALT AST and GGT levels as compared to the negative control rabbits. Therefore CO pulp and kernel oils are somehow not hepatotoxic and the oils are potent functional foods.

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Item Type:	Article
AGROVOC Term:	Canarium
AGROVOC Term:	Palm kernel oil
AGROVOC Term:	Rabbits
AGROVOC Term:	Functional foods
AGROVOC Term:	Fat content
AGROVOC Term:	Toxicity
AGROVOC Term:	Terpenoids
AGROVOC Term:	Cyanogenic glycosides
AGROVOC Term:	Crude oil
AGROVOC Term:	Centrifugation
Geographical Term:	Malaysia
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	26 Apr 2025 16:44
URI:	http://webagris.upm.edu.my/id/eprint/22120

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