Anti-hypoglycemic effect of aqueous leaf extract of Siamese neem tree (Azadirachta indica) in Plasmodium berghei infected mice

Somsak V., . and Srichairatanakool S., . and Uthaipibull C., . Anti-hypoglycemic effect of aqueous leaf extract of Siamese neem tree (Azadirachta indica) in Plasmodium berghei infected mice. pp. 885-888. ISSN 2231-7546

Hypoglycemia has been reported during malaria infection in blood stage and can cause of death in malaria endemic countries. Hence in this study was aimed to evaluate anti-hypoglycemic effect of Siamese neem tree extract in P. berghei infected mice. The aqueous leaf extract of Siamese neem tree was freshly prepared and used for orally treatment. Groups of ICR mice were infected intraperitoneally with 6x106 infected erythrocytes of P. berghei ANKA and subsequently given with the extract twice a day for 4 consecutive days. Blood glucose levels were then measured. Normal and untreated mice were used as healthy and disease controls respectively. The results showed that hypoglycemia was developed during P. berghei ANKA infection in mice as indicated by decreasing of blood glucose level. However blood glucose level in the extract treated mice was similar to normal group. It can be summarized that aqueous leaf extract of Siamese neem tree exhibited anti-hypoglycemic effect against P. berghei ANKA infected mice.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/23%20(02)%202016/(60).p...

Abstract

Hypoglycemia has been reported during malaria infection in blood stage and can cause of death in malaria endemic countries. Hence in this study was aimed to evaluate anti-hypoglycemic effect of Siamese neem tree extract in P. berghei infected mice. The aqueous leaf extract of Siamese neem tree was freshly prepared and used for orally treatment. Groups of ICR mice were infected intraperitoneally with 6x106 infected erythrocytes of P. berghei ANKA and subsequently given with the extract twice a day for 4 consecutive days. Blood glucose levels were then measured. Normal and untreated mice were used as healthy and disease controls respectively. The results showed that hypoglycemia was developed during P. berghei ANKA infection in mice as indicated by decreasing of blood glucose level. However blood glucose level in the extract treated mice was similar to normal group. It can be summarized that aqueous leaf extract of Siamese neem tree exhibited anti-hypoglycemic effect against P. berghei ANKA infected mice.

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Item Type:	Article
AGROVOC Term:	Azadirachta indica
AGROVOC Term:	Plasmodium berghei
AGROVOC Term:	Extracts
AGROVOC Term:	Leaf
AGROVOC Term:	Glucose
AGROVOC Term:	Hypoglycemia
AGROVOC Term:	Malaria
AGROVOC Term:	Erythrocytes
AGROVOC Term:	Thailand
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	24 Apr 2025 06:27
URI:	http://webagris.upm.edu.my/id/eprint/22675

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