The in vitro bactericidal activity of normal and activated Mouse Macrophages against Salmonella typhimurium C5sr

M. Musa, . and Rowley D., . The in vitro bactericidal activity of normal and activated Mouse Macrophages against Salmonella typhimurium C5sr. pp. 45-52. ISSN 0126-6128

A comparison of the in vitro bactericidal activity of normal and activated macrophages indicated that killing of the virulent strain of opsonized Salmonella typhimurium C5sr by normal macrophages was enhanced by the presence of fresh serum in the culture medium. In contrast there was no such requirement for the bactericidal activity of activated macrophages. The enhanced killing of the bacteria by activated macrophages occurred both in the presence and absence of serum and this was not accounted for by the existence of macrophage bound immunoglobulin. The factors in normal rabbit serum which potentiated the killing of bacteria by normal macrophages were suspected to be components of the complement system. Heat-stable factors (immunoglobulins) in normal rabbit serum were effective only if they were surface bound immunoglobulins.

Full text available from: Official URL: http://psasir.upm.edu.my/id/eprint/2913/1/The_In_V...

Abstract

A comparison of the in vitro bactericidal activity of normal and activated macrophages indicated that killing of the virulent strain of opsonized Salmonella typhimurium C5sr by normal macrophages was enhanced by the presence of fresh serum in the culture medium. In contrast there was no such requirement for the bactericidal activity of activated macrophages. The enhanced killing of the bacteria by activated macrophages occurred both in the presence and absence of serum and this was not accounted for by the existence of macrophage bound immunoglobulin. The factors in normal rabbit serum which potentiated the killing of bacteria by normal macrophages were suspected to be components of the complement system. Heat-stable factors (immunoglobulins) in normal rabbit serum were effective only if they were surface bound immunoglobulins.

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Item Type:	Article
AGROVOC Term:	Salmonella typhimurium
AGROVOC Term:	In vitro
AGROVOC Term:	Bacteria
AGROVOC Term:	Testing
AGROVOC Term:	Cells
AGROVOC Term:	Macrophages
AGROVOC Term:	Culture media
AGROVOC Term:	Immunoglobulins
Geographical Term:	Malaysia
Depositing User:	Ms. Suzila Mohamad Kasim
Last Modified:	28 Apr 2025 00:11
URI:	http://webagris.upm.edu.my/id/eprint/22817

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