Citation
Chow T. W., . and Yang K. L., . and Ong M. T., . and Lam K. L., . and Chai Y. L., . and Sunderasan E, . Susceptibility of Human B Lymphocyte cell lines to dialysed latex B- and C-sera fractions. pp. 187-195. ISSN 1511-1768
Abstract
Hevea brasiliensis latex sera are being investigated for anticancer property. In the present cell-based assay whole latex B- and C-sera were shown to be largely ineffective against human B lymphocytes of both cancer origin (BDCM) and non-cancer origin (Bristol 8); albeit slight dip in cell viability were discerned at high concentrations (100 g/mL) of whole C-serum and (200 g/mL) of whole B-serum. Interestingly the antiproliferative activity improved in the retentate of dialysed C-serum the increment however was more prominent in the dialysed C-serum precipitate (DCP) compared to the dialysed C-serum supernatant (DCS). DCP also showed a marginally higher specificity against BDCM (LC50 55.95 g/mL) compared to Bristol 8 (LC50 75.62 g/mL). However in the treatments with the retentate of dialysed B-serum both BDCM and Bristol 8 cells remained unaffected.
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Abstract
Hevea brasiliensis latex sera are being investigated for anticancer property. In the present cell-based assay whole latex B- and C-sera were shown to be largely ineffective against human B lymphocytes of both cancer origin (BDCM) and non-cancer origin (Bristol 8); albeit slight dip in cell viability were discerned at high concentrations (100 g/mL) of whole C-serum and (200 g/mL) of whole B-serum. Interestingly the antiproliferative activity improved in the retentate of dialysed C-serum the increment however was more prominent in the dialysed C-serum precipitate (DCP) compared to the dialysed C-serum supernatant (DCS). DCP also showed a marginally higher specificity against BDCM (LC50 55.95 g/mL) compared to Bristol 8 (LC50 75.62 g/mL). However in the treatments with the retentate of dialysed B-serum both BDCM and Bristol 8 cells remained unaffected.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Latex |
| AGROVOC Term: | Lymphocytes |
| AGROVOC Term: | Dialysis |
| AGROVOC Term: | Cells |
| AGROVOC Term: | Natural rubber |
| AGROVOC Term: | Cytoplasm |
| AGROVOC Term: | Cell culture |
| AGROVOC Term: | Hevea brasiliensis |
| Geographical Term: | Malaysia |
| Depositing User: | Ms. Suzila Mohamad Kasim |
| Last Modified: | 28 Apr 2025 02:31 |
| URI: | http://webagris.upm.edu.my/id/eprint/22998 |
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