Total phenolic and flavonoid contents and free radical scavenging components of Ficus nota Merr. (Moraceae) ethanolic leaf extract


Citation

Guerrero R. P., . and Saguinsin S. G. C., . and Nuguid A. M. N., . and Santiago L. A., . and Reyes A. M. L., . and Santos A. C. N., . Total phenolic and flavonoid contents and free radical scavenging components of Ficus nota Merr. (Moraceae) ethanolic leaf extract. pp. 2050-2058. ISSN 2231-7546

Abstract

The leaves of Ficus nota or tibig� are traditionally consumed as vegetable or used as herbal remedy. The primary aim of this research was to further evaluate the antioxidant and prooxidant nature of the plant by subjecting the ethanolic leaf extract containing alkaloids flavonoids phenols terpenoids saponins and tannins to various general and specific antioxidant assays. Total phenolic and flavonoid content were found to be 348.3 3.2 mg GAE/g and 2.64 0.06 mg QE/g. The extract exhibited a concentration dependent inhibitory effect on DPPH ABTS and nitric oxide radical with an EC50 of 970.6 269.8 and 5000 ppm respectively. Stimulation of superoxide hydrogen peroxide and hydroxyl radicals with median concentrations above 785.2 ppm was observed. The extract also showed a high dose dependent reducing capacity (EC50 548.3 ppm) and metal chelating potential (EC5027.53 ppm) towards iron. Results revealed that the plant extract possess both antioxidant and prooxidant properties depending on the concentration by which they are used. The dual nature exhibited by F. nota is deemed beneficial for the treatment and prevention of cardiovascular disease diabetes cancer and aging. It can also aid in the maintenance of cellular homeostasis host defense mechanisms and various signaling processes in the body.


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Abstract

The leaves of Ficus nota or tibig� are traditionally consumed as vegetable or used as herbal remedy. The primary aim of this research was to further evaluate the antioxidant and prooxidant nature of the plant by subjecting the ethanolic leaf extract containing alkaloids flavonoids phenols terpenoids saponins and tannins to various general and specific antioxidant assays. Total phenolic and flavonoid content were found to be 348.3 3.2 mg GAE/g and 2.64 0.06 mg QE/g. The extract exhibited a concentration dependent inhibitory effect on DPPH ABTS and nitric oxide radical with an EC50 of 970.6 269.8 and 5000 ppm respectively. Stimulation of superoxide hydrogen peroxide and hydroxyl radicals with median concentrations above 785.2 ppm was observed. The extract also showed a high dose dependent reducing capacity (EC50 548.3 ppm) and metal chelating potential (EC5027.53 ppm) towards iron. Results revealed that the plant extract possess both antioxidant and prooxidant properties depending on the concentration by which they are used. The dual nature exhibited by F. nota is deemed beneficial for the treatment and prevention of cardiovascular disease diabetes cancer and aging. It can also aid in the maintenance of cellular homeostasis host defense mechanisms and various signaling processes in the body.

Additional Metadata

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Item Type: Article
AGROVOC Term: Ficus
AGROVOC Term: Moraceae
AGROVOC Term: Leaves
AGROVOC Term: Medicinal plants
AGROVOC Term: Cardiovascular diseases
AGROVOC Term: Cardiovascular system
AGROVOC Term: Defence mechanisms
AGROVOC Term: Diabetes
AGROVOC Term: Extracts
AGROVOC Term: Phenolic content
Depositing User: Ms. Suzila Mohamad Kasim
Last Modified: 24 Apr 2025 06:28
URI: http://webagris.upm.edu.my/id/eprint/23843

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