Effects of paracetamol on the development of zebrafish (Danio rerio)

Dewanti, Ajeng Istyorini Asmoning, . and Kunjirika, Tony Prince, . and Putri, Raden Roro Risang Ayu Dewayani, . and Adaninggar, Ascarti, . and Raharjeng, Anita Restu Puji, . and Retnoaji, Bambang, . and Nuriliani, Ardaning, . and Sofyantoro, Fajar, . and Septriani, Nur Indah, . and Saragih, Hendry T. S. S. G., . (2023) Effects of paracetamol on the development of zebrafish (Danio rerio). Pertanika Journal Tropical Agricultural Science (Malaysia), 46 (4). pp. 1173-1188. ISSN 1511-3701

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.

Full text available from: Official URL: http://www.pertanika.upm.edu.my/resources/files/Pe...

Abstract

The misuse of paracetamol is becoming more prevalent worldwide. Due to non-compliance with recommended dosage and regulations, paracetamol consumption can result in serious health issues such as liver necrosis, kidney damage, heart damage, and hematological changes. This study sought to investigate the impact of paracetamol on the development of zebrafish embryos, which are often used as a model for assessing the effect of drug exposure on animals. The results indicated that paracetamol negatively affects the hatching and survival rates of zebrafish. Additionally, paracetamol exposure caused spinal abnormalities, pericardial edema, hypopigmentation, reduced heart rate, and spontaneous movement in zebrafish larvae. The developmental abnormalities in zebrafish were more significant with higher concentrations and longer exposure times. These findings may provide valuable insights into the detrimental impact of paracetamol on aquatic animals.

[error in script]

Item Type:	Article
AGROVOC Term:	Danio rerio
AGROVOC Term:	embryonic development
AGROVOC Term:	drugs
AGROVOC Term:	pigmentation
AGROVOC Term:	experimentation
AGROVOC Term:	statistical methods
AGROVOC Term:	aquatic ecosystems
Geographical Term:	Indonesia
Uncontrolled Keywords:	zebrafish
Depositing User:	Ms. Azariah Hashim
Date Deposited:	17 Nov 2025 08:02
Last Modified:	17 Nov 2025 08:02
URI:	http://webagris.upm.edu.my/id/eprint/2520

Actions (login required)

View Item