Efficacy of different administrative routes of NDVAC 1174/08 in broilers

Niny Fariza J., . and Iswadi M. I., . and Jamaliah H., . and Goon, S. C. and Chin, S. W. and Suriani M. N., . and Norazura A. H., . and Jabir J., . (2023) Efficacy of different administrative routes of NDVAC 1174/08 in broilers. Malaysian Journal of Veterinary Research (Malaysia), 14 (1). pp. 56-60. ISSN 2180-3897

The performance of NDVAC 1174/08 developed by the Veterinary Research Institute (VRI) was assessed through different routes of administration in broiler chickens. 30 broiler chickens of 25 days old, mixed sex, and unrecorded weight were commercially purchased for this study and were divided equally into three groups according to the routes of administration, which are intramuscular, intranasal, and control group. All broilers except for the control group were vaccinated once when they were 26 days old with a NDVAC 1174/08 dose of 106.5/ per bird, whether intramuscular or intranasal. Phosphate buffer saline (PBS) was administered by intranasal as placebo for the control group. Serum sample from all broilers were taken at 3, 5, 7, 10, 14, 21, and 28 days day post vaccination (dpv). The Haemagglutination Inhibition (HI) test was used to identify Newcastle Disease (ND) antibodies in all serum samples. Results for the effectiveness of the intramuscular method showed mean HI titer (Log 2 ) of 4.35 beginning to rise at 7 dpv. On the other hand, intranasal route exhibited mean HI titer (Log₂ ) 4 beginning at 10 dpv. No antibodies of ND were found in control group. NDVAC1174/08 demonstrated better antibody response through intramuscular route as compared to the intranasal route.

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Abstract

The performance of NDVAC 1174/08 developed by the Veterinary Research Institute (VRI) was assessed through different routes of administration in broiler chickens. 30 broiler chickens of 25 days old, mixed sex, and unrecorded weight were commercially purchased for this study and were divided equally into three groups according to the routes of administration, which are intramuscular, intranasal, and control group. All broilers except for the control group were vaccinated once when they were 26 days old with a NDVAC 1174/08 dose of 106.5/ per bird, whether intramuscular or intranasal. Phosphate buffer saline (PBS) was administered by intranasal as placebo for the control group. Serum sample from all broilers were taken at 3, 5, 7, 10, 14, 21, and 28 days day post vaccination (dpv). The Haemagglutination Inhibition (HI) test was used to identify Newcastle Disease (ND) antibodies in all serum samples. Results for the effectiveness of the intramuscular method showed mean HI titer (Log 2 ) of 4.35 beginning to rise at 7 dpv. On the other hand, intranasal route exhibited mean HI titer (Log₂ ) 4 beginning at 10 dpv. No antibodies of ND were found in control group. NDVAC1174/08 demonstrated better antibody response through intramuscular route as compared to the intranasal route.

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Item Type:	Article
AGROVOC Term:	broiler chickens
AGROVOC Term:	Newcastle disease
AGROVOC Term:	vaccines
AGROVOC Term:	vaccination
AGROVOC Term:	intramuscular injection
AGROVOC Term:	Newcastle disease virus
AGROVOC Term:	haemagglutination inhibition tests
AGROVOC Term:	antibodies
Geographical Term:	Malaysia
Depositing User:	Mr. Khoirul Asrimi Md Nor
Date Deposited:	20 Jun 2025 02:38
Last Modified:	20 Jun 2025 02:38
URI:	http://webagris.upm.edu.my/id/eprint/2872

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