Health effects of peptides obtained from hydrolysed chicken by-products by the action of Bromelia pinguin and B. karatas proteases in Wistar rats induced with metabolic syndrome

Romero Garay, M. G and Becerra Verdín, E. M. and Soto Domínguez, A. and Montalvo González, E. and García Magaña, M. L. (2022) Health effects of peptides obtained from hydrolysed chicken by-products by the action of Bromelia pinguin and B. karatas proteases in Wistar rats induced with metabolic syndrome. International Food Research Journal (Malaysia), 29. pp. 1079-1088. ISSN 2231 7546

Metabolic syndrome (MS) is considered a major public health problem because it is associated with the development of cardiovascular disease and type 2 diabetes. Bioactive peptides can play an important role in the prevention and treatment of MS. The possible health effects of peptides obtained from hydrolysed chicken by-products (CH) by the action of plant proteases from Bromelia pinguin (BP), B. karatas (BK), and bromelain (BRO) were evaluated in a model of induced MS. Thirty male Wistar rats were randomised into the following groups: (1) standard diet (STD); (2) induction of MS with a hypercaloric diet (MS+CH); (3) CH-BP 200 mg CH/kg; (4) CH-BK 200 mg CH/kg; (5) CH-BRO 200 mg CH/kg; and (6) carnosine (CAR) 50 mg of carnosine/kg of body weight. The CH decreased the glucose levels (p < 0.05) and improved the lipid profile (p < 0.05) in the serum of the groups with induced MS. Liver lesions were attenuated with a decrease in hepatic enzymatic activities (p < 0.05), and the accumulation of lipid inclusions in the liver decreased. The data showed that CH and the use of proteases to obtain peptides with health effects could be a good therapeutic alternative for individuals with MS.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/29%20(05)%202022/10%20-...

Abstract

Metabolic syndrome (MS) is considered a major public health problem because it is associated with the development of cardiovascular disease and type 2 diabetes. Bioactive peptides can play an important role in the prevention and treatment of MS. The possible health effects of peptides obtained from hydrolysed chicken by-products (CH) by the action of plant proteases from Bromelia pinguin (BP), B. karatas (BK), and bromelain (BRO) were evaluated in a model of induced MS. Thirty male Wistar rats were randomised into the following groups: (1) standard diet (STD); (2) induction of MS with a hypercaloric diet (MS+CH); (3) CH-BP 200 mg CH/kg; (4) CH-BK 200 mg CH/kg; (5) CH-BRO 200 mg CH/kg; and (6) carnosine (CAR) 50 mg of carnosine/kg of body weight. The CH decreased the glucose levels (p < 0.05) and improved the lipid profile (p < 0.05) in the serum of the groups with induced MS. Liver lesions were attenuated with a decrease in hepatic enzymatic activities (p < 0.05), and the accumulation of lipid inclusions in the liver decreased. The data showed that CH and the use of proteases to obtain peptides with health effects could be a good therapeutic alternative for individuals with MS.

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Item Type:	Article
AGROVOC Term:	metabolic disorders
AGROVOC Term:	health risks > health risks Prefer using health hazardshealth hazards
AGROVOC Term:	enzymatic hydrolysis
AGROVOC Term:	peptides
AGROVOC Term:	lipid content
AGROVOC Term:	statistical analysis > statistical analysis Prefer using statistical methodsstatistical methods
AGROVOC Term:	functional foods
Geographical Term:	Mexico
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	05 Sep 2024 08:07
Last Modified:	05 Sep 2024 08:07
URI:	http://webagris.upm.edu.my/id/eprint/38

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