Effect of vitamin D supplementation on serum 25(OH) D levels and blood pressure among the elderly in a nursing house: A double-blind, randomised placebocontrolled trial

Ferawaty, . and Diana Sunardi, . and Noto Dwimartutie, . and Dian Novita Chandra, . and Ninik Mudjihartin, . and Nurul Ratna Mutu Manikam, . (2024) Effect of vitamin D supplementation on serum 25(OH) D levels and blood pressure among the elderly in a nursing house: A double-blind, randomised placebocontrolled trial. Malaysian Journal of Nutrition (Malaysia), 30 (2). pp. 153-165. ISSN 1394 – 035X

Introduction: Hypertension is the most common cardiovascular disease, especially in the elderly. Previous studies have reported that vitamin D plays a role in blood pressure. This study aimed to analyse the effect of vitamin D supplementation on serum 25(OH)D levels and blood pressure. Methods: This was a double-blind, randomised placebo-controlled trial (RCT) on elderly subjects. Serum 25(OH)D levels were examined using chemiluminescent immunoassay (CLIA) method, while blood pressure was checked using a digital sphygmomanometer. Supplementation was given once per day for eight weeks; the control group was given a placebo, while the treatment group was given 2,000 IU vitamin D₃ for subjects with insufficiency and 4,000 IU for subjects with deficiency. Results: A total of 62 subjects aged 60-89 years participated and were randomised into 30 control and 32 treatment group subjects. Data analysis showed that vitamin D supplementation significantly increased 25(OH)D levels in treatment group (D=18.2±5.2 ng/mL) compared to control group (D=4.2±2.5 ng/mL) (p<0.001). However, vitamin D supplementation did not cause significant reduction in systolic blood pressure (D=-4.6(-25 - -0.5) mmHg for control group and D=-9.2(-20 - -27) mmHg for treatment group; p=0.109), and diastolic blood pressure (D=-7.2(-16 - -2) mmHg for control group and D=-8.4(-14.5 - -8.5) mmHg for treatment group; p=0.559). Conclusion: Vitamin D supplementation significantly increased serum 25(OH)D levels, but did not significantly reduce systolic and diastolic blood pressures in the elderly. Elderly people need to regularly check their vitamin D levels so that the provision of supplementation can be timely and their quality of life can be improved.

Full text available from: Official URL: https://maljnutr.org.my/publication/30-2/Vol%2030(...

Abstract

Introduction: Hypertension is the most common cardiovascular disease, especially in the elderly. Previous studies have reported that vitamin D plays a role in blood pressure. This study aimed to analyse the effect of vitamin D supplementation on serum 25(OH)D levels and blood pressure. Methods: This was a double-blind, randomised placebo-controlled trial (RCT) on elderly subjects. Serum 25(OH)D levels were examined using chemiluminescent immunoassay (CLIA) method, while blood pressure was checked using a digital sphygmomanometer. Supplementation was given once per day for eight weeks; the control group was given a placebo, while the treatment group was given 2,000 IU vitamin D₃ for subjects with insufficiency and 4,000 IU for subjects with deficiency. Results: A total of 62 subjects aged 60-89 years participated and were randomised into 30 control and 32 treatment group subjects. Data analysis showed that vitamin D supplementation significantly increased 25(OH)D levels in treatment group (D=18.2±5.2 ng/mL) compared to control group (D=4.2±2.5 ng/mL) (p<0.001). However, vitamin D supplementation did not cause significant reduction in systolic blood pressure (D=-4.6(-25 - -0.5) mmHg for control group and D=-9.2(-20 - -27) mmHg for treatment group; p=0.109), and diastolic blood pressure (D=-7.2(-16 - -2) mmHg for control group and D=-8.4(-14.5 - -8.5) mmHg for treatment group; p=0.559). Conclusion: Vitamin D supplementation significantly increased serum 25(OH)D levels, but did not significantly reduce systolic and diastolic blood pressures in the elderly. Elderly people need to regularly check their vitamin D levels so that the provision of supplementation can be timely and their quality of life can be improved.

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Item Type:	Article
AGROVOC Term:	vitamin D
AGROVOC Term:	blood pressure
AGROVOC Term:	hypertension
AGROVOC Term:	cardiovascular diseases
AGROVOC Term:	food supplementation
AGROVOC Term:	elderly
AGROVOC Term:	data analysis
AGROVOC Term:	quality of life
AGROVOC Term:	public health
Geographical Term:	Indonesia
Uncontrolled Keywords:	blood pressure, elderly, serum 25(OH)D level, vitamin D supplementation
Depositing User:	Ms. Azariah Hashim
Date Deposited:	23 Jul 2026 00:44
Last Modified:	23 Jul 2026 00:44
URI:	http://webagris.upm.edu.my/id/eprint/4083

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