Predictors for 25-hydroxyvitamin D concentration in early pregnancy

Erni Yusnita Lalusu, . and Ratna Djuwita Hatma, . and Mondastri Korib Sudaryo, . and Dwiana Ocviyanti, . and Rimbawan, . (2024) Predictors for 25-hydroxyvitamin D concentration in early pregnancy. Malaysian Journal of Nutrition (Malaysia), 30 (2). pp. 181-191. ISSN 1394 – 035X

Introduction: There are very few studies of vitamin D deficiency in Indonesia. Since vitamin D deficiency is indicated by the level of 25-hydroxyvitamin D (25(OH) D) in blood, the present study aimed to analyse the predictive factors of 25(OH) D concentration in early pregnancy. Methods: The present study was a crosssectional observational study. The sample consisted of 67 pregnant women in their 1ˢᵗ trimester of pregnancy. Parameters assessed included levels of 25(OH)D, glucose, and haemoglobin in the blood. Demographic information such as parity, family history of diabetes mellitus (DM), exposure to cigarette smoke, physical activity level, dietary intake, and anthropometric measurements were recorded. Linear regression analysis was employed. Results: Mean concentration of 25(OH)D was 16.5 (6.6-34.1) ng/ml. Majority of the participants (77.6%) were deficient in vitamin D (25(OH)D <20ng/mL); only 1.5% had normal vitamin D levels (25(OH)D >30 ng/ mL). Bivariate analysis performed revealed that vitamin D intake (p=0.002) and family history of DM (p=0.043) played a significant role in determining 25(OH)D concentration. Additionally, dietary vitamin D intake, blood glucose level, exposure to cigarette smoke, and parental DM history served as predictors of 25(OH)D concentration in 54.5% of cases. Conclusion: The findings indicate that vitamin D deficiency was high in the target population. Thus, it is critical to ensure that for pregnant women to take vitamin D supplements, since nearly 80% of pregnant mothers are vit D deficient. Vitamin D supplementation can be included in national pregnancy programmes

Full text available from: Official URL: https://maljnutr.org.my/publication/30-2/Vol%2030(...

Abstract

Introduction: There are very few studies of vitamin D deficiency in Indonesia. Since vitamin D deficiency is indicated by the level of 25-hydroxyvitamin D (25(OH) D) in blood, the present study aimed to analyse the predictive factors of 25(OH) D concentration in early pregnancy. Methods: The present study was a crosssectional observational study. The sample consisted of 67 pregnant women in their 1ˢᵗ trimester of pregnancy. Parameters assessed included levels of 25(OH)D, glucose, and haemoglobin in the blood. Demographic information such as parity, family history of diabetes mellitus (DM), exposure to cigarette smoke, physical activity level, dietary intake, and anthropometric measurements were recorded. Linear regression analysis was employed. Results: Mean concentration of 25(OH)D was 16.5 (6.6-34.1) ng/ml. Majority of the participants (77.6%) were deficient in vitamin D (25(OH)D <20ng/mL); only 1.5% had normal vitamin D levels (25(OH)D >30 ng/ mL). Bivariate analysis performed revealed that vitamin D intake (p=0.002) and family history of DM (p=0.043) played a significant role in determining 25(OH)D concentration. Additionally, dietary vitamin D intake, blood glucose level, exposure to cigarette smoke, and parental DM history served as predictors of 25(OH)D concentration in 54.5% of cases. Conclusion: The findings indicate that vitamin D deficiency was high in the target population. Thus, it is critical to ensure that for pregnant women to take vitamin D supplements, since nearly 80% of pregnant mothers are vit D deficient. Vitamin D supplementation can be included in national pregnancy programmes

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Item Type:	Article
AGROVOC Term:	vitamin D
AGROVOC Term:	food supplementation
AGROVOC Term:	pregnancy
AGROVOC Term:	physical activity
AGROVOC Term:	haemoglobin
AGROVOC Term:	anthropometry
AGROVOC Term:	bioconcentration
AGROVOC Term:	deficiency diseases
Geographical Term:	Indonesia
Uncontrolled Keywords:	cigarette, diabetes mellitus, pregnant women, vitamin D concentration, vitamin D intake
Depositing User:	Ms. Azariah Hashim
Date Deposited:	23 Jul 2026 00:43
Last Modified:	23 Jul 2026 00:43
URI:	http://webagris.upm.edu.my/id/eprint/4084

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