In vitro antioxidant and anticholinesterase activities of ethanolic turmeric crude extract

Abbas, S. and Latif, S. M. and Muhamad, I. I. and Hesan, M. A. and Kormin, F. (2022) In vitro antioxidant and anticholinesterase activities of ethanolic turmeric crude extract. Food Research (Malaysia), 6 (4). pp. 199-204. ISSN 2550-2166

This study was aimed at exploring the antioxidant and anticholinesterase effect of ethanolic turmeric crude extract. The antioxidant activity was determined by using the 1,1- diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity, (2,2'-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid)) (ABTS) and ferric reducing antioxidant power (FRAP) values. Ethanolic crude extract of turmeric showed good antioxidant and anticholinesterase activities (% I); the activity was, 80.2±1.30%, 75.6±1.23% and 10.43±0.28% for ABTS, DPPH and FRAP, respectively, and 69.0±1.85% and 70.5±1.11% for AChE and BChE, respectively. However, the maximum% I for ABTS, DPPH and FRAP, that is, 87.2±1.34%, 86.0±1.59% and 19.36±0.37 µg FSE, respectively, were shown by positive control ascorbic acid, and for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition, 86.69±1.24 and 89.3±1.01%, respectively, by galanthamine. Turmeric provides a potential natural source of bioactive compounds and is valuable to human health.

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Abstract

This study was aimed at exploring the antioxidant and anticholinesterase effect of ethanolic turmeric crude extract. The antioxidant activity was determined by using the 1,1- diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity, (2,2'-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid)) (ABTS) and ferric reducing antioxidant power (FRAP) values. Ethanolic crude extract of turmeric showed good antioxidant and anticholinesterase activities (% I); the activity was, 80.2±1.30%, 75.6±1.23% and 10.43±0.28% for ABTS, DPPH and FRAP, respectively, and 69.0±1.85% and 70.5±1.11% for AChE and BChE, respectively. However, the maximum% I for ABTS, DPPH and FRAP, that is, 87.2±1.34%, 86.0±1.59% and 19.36±0.37 µg FSE, respectively, were shown by positive control ascorbic acid, and for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition, 86.69±1.24 and 89.3±1.01%, respectively, by galanthamine. Turmeric provides a potential natural source of bioactive compounds and is valuable to human health.

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Item Type:	Article
AGROVOC Term:	turmeric
AGROVOC Term:	laboratory experimentation
AGROVOC Term:	biochemists
AGROVOC Term:	bioactive compounds
AGROVOC Term:	enzyme inhibitors
Geographical Term:	Malaysia
Uncontrolled Keywords:	Antioxidants, Anticholinesterase
Depositing User:	Ms. Azariah Hashim
Date Deposited:	01 Nov 2024 03:35
Last Modified:	01 Nov 2024 03:35
URI:	http://webagris.upm.edu.my/id/eprint/663

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