Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats

Rajesh Ramasamy, . and Asmah Rahmat, . and Pratheep Sandrasaigaran, . and Shalini Vellasamy, . and Mojani Mansooreh Sadat, . and Seyed Majid A. H., . and Vahid Hosseinpour Sarmadi, . Metabolic and immunologic alterations of ginger rhizome among streptozotocin-nicotinamide induced diabetic rats. pp. 421-432. ISSN 1394-035X

Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w 15 min after NA). Diabetic rats orally received either different concentrations (250 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight fasting blood glucose level of triglyceride and tumor necrosis factor- (TNF-) (p0.05). In contrast ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 g/ml PHA (p0.001). Level of CD45ra (B cell marker) increased significantly in the lowest dose of ginger (p0.05) 58) and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4CD25 marker (p0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment.

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Abstract

Introduction: This study was conducted to determine immunological and metabolic effects of different concentrations of ginger rhizome (Zingiber officinale Roscoe) in streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Methods: Forty-eight fasted male Sprague-Dawley rats were induced diabetes using a single intraperitoneal injection of NA(110 mg/kg b.w.) and STZ (65 mg/kg b.w 15 min after NA). Diabetic rats orally received either different concentrations (250 500 and 750 mg/kg body weight) of ginger rhizome suspension or glibenclamide (10 mg/kg body weight) for 6 weeks. Two control diabetic and normal groups were gavaged with only distilled water as a vehicle. Results: The results indicated that the lower concentrations of ginger modulated body weight fasting blood glucose level of triglyceride and tumor necrosis factor- (TNF-) (p0.05). In contrast ginger could not enhance atherogenic indices due to a decline in the level of HDL-c. Immunological features of ginger were evident by a significant lymphocyte proliferation in all treated groups at stimulation by 5 g/ml PHA (p0.001). Level of CD45ra (B cell marker) increased significantly in the lowest dose of ginger (p0.05) 58) and 250 mg/kg body weight of ginger was found to be safe for not altering the level of CD4CD25 marker (p0.05). Conclusion: Ginger indicated better impact on metabolic and immunologic parameters in lower doses of supplementation compared with high doses of treatment.

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Item Type:	Article
AGROVOC Term:	Zingiber officinale
AGROVOC Term:	Zingiberaceae
AGROVOC Term:	Diabetes
AGROVOC Term:	Rats
AGROVOC Term:	Blood glucose
AGROVOC Term:	Male animals
AGROVOC Term:	Body weight
AGROVOC Term:	Nicotinamide
AGROVOC Term:	Freeze drying
AGROVOC Term:	Ginger
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7858

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