Hepato-protective effects of blue-green alga Spirulina platensis on diclofenac-induced liver injury in rats

Patel D. Samixaben, . and Sangeetha L. A. R., . and Pandanaboina Chetan S., . Hepato-protective effects of blue-green alga Spirulina platensis on diclofenac-induced liver injury in rats. pp. 289-299. ISSN 1394-035X

Introduction: This research aimed at evaluating the hepato-protective effect of the alga Spirulina platensis against diclofenac-induced liver injury in rats. The studys ultimate aim was to understand whether Spirulina could be developed as a functional food for therapy and protective therapeutic use. Methods: Hepatic injury was induced by administering diclofenac sodium (50mg/kg i.p.) for 5 days. S. platensis dose (300mg/kg) was administered to rats (180-220 g) orally for 5 days. On day 3 and day 4 after Spirulina dosage diclofenac was administered. The reference drug silymarin was used in the study. Antioxidant activities like superoxide dismutase (SOD) activity catalase (CAT) activity reduced glutathione (GSH) and lipid peroxidation (LPO) glutamate-pyruvate transaminase (GPT) glutamate-oxaloacetate transaminase (GOT) alkaline phosphatase (AlP) activities and levels of total protein total bilirubin direct bilirubin and lipid profiles including high density lipoproteins (HDL) low density lipoproteins (LDL) very-low-density lipoprotein (VLDL) triglycerides and total cholesterol in serum were determined and compared with animals treated with diclofenac alone. Results: Animals receiving S. platensis prior to the administration of diclofenac significantly counteracted the diclofenac-induced changes decreasing GPT GOT and AlP activities total bilirubin LDL and total cholesterol in serum and lipid peroxidation in liver tissue. Spirulina-treated rats revealed similar results to those treated with silymarin. Conclusion: These results combined with hepatic histopathological observations demonstrated that S. platensis has potential hepato-protective effect against diclofenac-induced hepatic injury in rats. More studies should be conducted to confirm the hepato-protective properties of S. platensis and its development as a potential functional food.

Full text available from: Official URL: http://www.nutriweb.org.my/mjn/publication/22-2/k....

Abstract

Introduction: This research aimed at evaluating the hepato-protective effect of the alga Spirulina platensis against diclofenac-induced liver injury in rats. The studys ultimate aim was to understand whether Spirulina could be developed as a functional food for therapy and protective therapeutic use. Methods: Hepatic injury was induced by administering diclofenac sodium (50mg/kg i.p.) for 5 days. S. platensis dose (300mg/kg) was administered to rats (180-220 g) orally for 5 days. On day 3 and day 4 after Spirulina dosage diclofenac was administered. The reference drug silymarin was used in the study. Antioxidant activities like superoxide dismutase (SOD) activity catalase (CAT) activity reduced glutathione (GSH) and lipid peroxidation (LPO) glutamate-pyruvate transaminase (GPT) glutamate-oxaloacetate transaminase (GOT) alkaline phosphatase (AlP) activities and levels of total protein total bilirubin direct bilirubin and lipid profiles including high density lipoproteins (HDL) low density lipoproteins (LDL) very-low-density lipoprotein (VLDL) triglycerides and total cholesterol in serum were determined and compared with animals treated with diclofenac alone. Results: Animals receiving S. platensis prior to the administration of diclofenac significantly counteracted the diclofenac-induced changes decreasing GPT GOT and AlP activities total bilirubin LDL and total cholesterol in serum and lipid peroxidation in liver tissue. Spirulina-treated rats revealed similar results to those treated with silymarin. Conclusion: These results combined with hepatic histopathological observations demonstrated that S. platensis has potential hepato-protective effect against diclofenac-induced hepatic injury in rats. More studies should be conducted to confirm the hepato-protective properties of S. platensis and its development as a potential functional food.

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Item Type:	Article
AGROVOC Term:	Spirulina platensis
AGROVOC Term:	Blue green algae
AGROVOC Term:	Animal models
AGROVOC Term:	Rats
AGROVOC Term:	Antioxidants
AGROVOC Term:	Liver diseases
AGROVOC Term:	Lipoproteins
AGROVOC Term:	Catalase
AGROVOC Term:	Glutathione
AGROVOC Term:	Silymarin
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:53
URI:	http://webagris.upm.edu.my/id/eprint/7872

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